Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells

التفاصيل البيبلوغرافية
العنوان:	Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells
المؤلفون:	Jonghyeob Lee, Emily R. Snyder, Yinghua Liu, Xueying Gu, Jing Wang, Brittany M. Flowers, Yoo Jung Kim, Sangbin Park, Gregory L. Szot, Ralph H. Hruban, Teri A. Longacre, Seung K. Kim
المصدر:	Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
بيانات النشر:	Nature Portfolio, 2017.
سنة النشر:	2017
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Models of human pancreatic intraepithelial neoplasia (PanIN) development do not exist. Here, the authors induce oncogenicKRAS and mutations in CDKN2A, SMAD4 and TP53in primary human pancreatic cells to generate a PanIN model that recapitulates molecular and pathologic features of native PanINs.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/ncomms14686
URL الوصول:	https://doaj.org/article/07f5f64889bc4267b1acdb73c8a62eac
رقم الأكسشن:	edsdoj.07f5f64889bc4267b1acdb73c8a62eac
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/ncomms14686