دورية أكاديمية

Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells

التفاصيل البيبلوغرافية
العنوان: Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells
المؤلفون: Ghazaleh M. Shahriary, Hardeep Kataria, Soheila Karimi-Abdolrezaee
المصدر: Stem Cells International, Vol 2019 (2019)
بيانات النشر: Wiley, 2019.
سنة النشر: 2019
المجموعة: LCC:Internal medicine
مصطلحات موضوعية: Internal medicine, RC31-1245
الوصف: Microglia play diverse roles in homeostasis and pathology of the central nervous system (CNS). Their response to injury or insult is critical for initiating neuroinflammation and tissue damage as well as resolution of inflammation and wound healing. Changes to the microenvironment of microglia appear to be a key determinant of their phenotype and their role in the endogenous repair process in the injured or diseased CNS. Our recent findings have identified a positive role for neuregulin-1 (Nrg-1) in regulating immune response in spinal cord injury and focal demyelinating lesions. We show that increasing the tissue availability of Nrg-1 after injury can promote endogenous repair by modulating neuroinflammation. In the present study, we sought to elucidate the specific role of Nrg-1 in regulating microglial activity and more importantly their influence on the behavior of neural stem/progenitor cells (NPCs). Using injury-relevant in vitro systems, we demonstrate that Nrg-1 attenuates the expression of proinflammatory mediators in activated microglia. Moreover, we provide novel evidence that availability of Nrg-1 can restore the otherwise suppressed phagocytic ability of proinflammatory microglia. Interestingly, the presence of Nrg-1 in the microenvironment of proinflammatory microglia mitigates their inhibitory effects on NPC proliferation. Nrg-1 treated proinflammatory microglia also augment mobilization of NPCs, while they had no influence on their suppressive effects on NPC differentiation. Mechanistically, we show that Nrg-1 enhances the interactions of proinflammatory microglia and NPCs, at least in part, through reduction of TNF-α expression in microglia. These findings provide new insights into the endogenous regulation of microglia-NPC interactions and identify new potential targets for optimizing this important crosstalk during the regenerative process after CNS injury and neuroinflammatory conditions.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-966X
1687-9678
Relation: https://doaj.org/toc/1687-966X; https://doaj.org/toc/1687-9678
DOI: 10.1155/2019/8397158
URL الوصول: https://doaj.org/article/08188ba4eda84917a096af6137c77ef2
رقم الأكسشن: edsdoj.08188ba4eda84917a096af6137c77ef2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1687966X
16879678
DOI:10.1155/2019/8397158