دورية أكاديمية
Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells
العنوان: | Neuregulin-1 Fosters Supportive Interactions between Microglia and Neural Stem/Progenitor Cells |
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المؤلفون: | Ghazaleh M. Shahriary, Hardeep Kataria, Soheila Karimi-Abdolrezaee |
المصدر: | Stem Cells International, Vol 2019 (2019) |
بيانات النشر: | Wiley, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Internal medicine |
مصطلحات موضوعية: | Internal medicine, RC31-1245 |
الوصف: | Microglia play diverse roles in homeostasis and pathology of the central nervous system (CNS). Their response to injury or insult is critical for initiating neuroinflammation and tissue damage as well as resolution of inflammation and wound healing. Changes to the microenvironment of microglia appear to be a key determinant of their phenotype and their role in the endogenous repair process in the injured or diseased CNS. Our recent findings have identified a positive role for neuregulin-1 (Nrg-1) in regulating immune response in spinal cord injury and focal demyelinating lesions. We show that increasing the tissue availability of Nrg-1 after injury can promote endogenous repair by modulating neuroinflammation. In the present study, we sought to elucidate the specific role of Nrg-1 in regulating microglial activity and more importantly their influence on the behavior of neural stem/progenitor cells (NPCs). Using injury-relevant in vitro systems, we demonstrate that Nrg-1 attenuates the expression of proinflammatory mediators in activated microglia. Moreover, we provide novel evidence that availability of Nrg-1 can restore the otherwise suppressed phagocytic ability of proinflammatory microglia. Interestingly, the presence of Nrg-1 in the microenvironment of proinflammatory microglia mitigates their inhibitory effects on NPC proliferation. Nrg-1 treated proinflammatory microglia also augment mobilization of NPCs, while they had no influence on their suppressive effects on NPC differentiation. Mechanistically, we show that Nrg-1 enhances the interactions of proinflammatory microglia and NPCs, at least in part, through reduction of TNF-α expression in microglia. These findings provide new insights into the endogenous regulation of microglia-NPC interactions and identify new potential targets for optimizing this important crosstalk during the regenerative process after CNS injury and neuroinflammatory conditions. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1687-966X 1687-9678 |
Relation: | https://doaj.org/toc/1687-966X; https://doaj.org/toc/1687-9678 |
DOI: | 10.1155/2019/8397158 |
URL الوصول: | https://doaj.org/article/08188ba4eda84917a096af6137c77ef2 |
رقم الأكسشن: | edsdoj.08188ba4eda84917a096af6137c77ef2 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 1687966X 16879678 |
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DOI: | 10.1155/2019/8397158 |