دورية أكاديمية
Models for the retention of duplicate genes and their biological underpinnings [version 2; peer review: 2 approved]
| العنوان: | Models for the retention of duplicate genes and their biological underpinnings [version 2; peer review: 2 approved] |
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| المؤلفون: | Amanda E. Wilson, David A. Liberles, Malgorzata M. O'Reilly, Gavin Conant, Barbara Holland, Raquel Assis |
| المصدر: | F1000Research, Vol 12 (2024) |
| بيانات النشر: | F1000 Research Ltd, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | gene duplication, probabilistic modeling, theoretical biology, Markov model, synteny, phylogenetic analysis, eng, Medicine, Science |
| الوصف: | Gene content in genomes changes through several different processes, with gene duplication being an important contributor to such changes. Gene duplication occurs over a range of scales from individual genes to whole genomes, and the dynamics of this process can be context dependent. Still, there are rules by which genes are retained or lost from genomes after duplication, and probabilistic modeling has enabled characterization of these rules, including their context-dependence. Here, we describe the biology and corresponding mathematical models that are used to understand duplicate gene retention and its contribution to the set of biochemical functions encoded in a genome. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2046-1402 |
| Relation: | https://f1000research.com/articles/12-1400/v2; https://doaj.org/toc/2046-1402 |
| DOI: | 10.12688/f1000research.141786.2 |
| URL الوصول: | https://doaj.org/article/dc085baba8f346fea848cc3a8d995af3 |
| رقم الأكسشن: | edsdoj.085baba8f346fea848cc3a8d995af3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20461402 |
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| DOI: | 10.12688/f1000research.141786.2 |