دورية أكاديمية
Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment
العنوان: | Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment |
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المؤلفون: | Carlos Virgous, Letitia Lyons, Amos Sakwe, Tultul Nayyar, Shawn Goodwin, James Hildreth, Kevin Osteen, Kaylon Bruner-Tran, Oluwatobi Alawode, Phillip Bourne, Edward Richard Hills, Anthony E. Archibong |
المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 11, p 9374 (2023) |
بيانات النشر: | MDPI AG, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | hydroxyurea, male contraception, testis weight, sperm density, sperm motility, testosterone, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Hydroxyurea (HU), a drug for treating cancers of the blood and the management of sickle cell anemia, induces hypogonadism in males. However, the impact of HU on testicular architecture and function, as well as its effects on the resumption of male fertility following treatment withdrawal, remain poorly understood. We used adult male mice to determine whether HU-induced hypogonadism is reversible. Fertility indices of mice treated with HU daily for ~1 sperm cycle (2 months) were compared with those of their control counterparts. All indices of fertility were significantly reduced among mice treated with HU compared to controls. Interestingly, significant improvements in fertility indices were apparent after a 4-month withdrawal from HU treatment (testis weight: month 1 post-HU withdrawal (M1): HU, 0.09 ± 0.01 vs. control, 0.33 ± 0.03; M4: HU, 0.26 ± 0.03 vs. control, 0.37 ± 0.04 g); sperm motility (M1: HU,12 vs. 59; M4: HU, 45 vs. control, 61%; sperm density (M1: HU, 1.3 ± 0.3 vs. control, 15.7 ± 0.9; M4: HU, 8.1 ± 2.5 vs. control, 16.8 ± 1.9 million). Further, circulating testosterone increased in the 4th month following HU withdrawal and was comparable to that of controls. When a mating experiment was conducted, recovering males sired viable offspring with untreated females albeit at a lower rate than control males (p < 0.05); therefore, qualifying HU as a potential candidate for male contraception. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/24/11/9374; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms24119374 |
URL الوصول: | https://doaj.org/article/087d18d3e5964dc2b0d472e612e74855 |
رقم الأكسشن: | edsdoj.087d18d3e5964dc2b0d472e612e74855 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
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DOI: | 10.3390/ijms24119374 |