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Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment

التفاصيل البيبلوغرافية
العنوان: Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment
المؤلفون: Carlos Virgous, Letitia Lyons, Amos Sakwe, Tultul Nayyar, Shawn Goodwin, James Hildreth, Kevin Osteen, Kaylon Bruner-Tran, Oluwatobi Alawode, Phillip Bourne, Edward Richard Hills, Anthony E. Archibong
المصدر: International Journal of Molecular Sciences, Vol 24, Iss 11, p 9374 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: hydroxyurea, male contraception, testis weight, sperm density, sperm motility, testosterone, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Hydroxyurea (HU), a drug for treating cancers of the blood and the management of sickle cell anemia, induces hypogonadism in males. However, the impact of HU on testicular architecture and function, as well as its effects on the resumption of male fertility following treatment withdrawal, remain poorly understood. We used adult male mice to determine whether HU-induced hypogonadism is reversible. Fertility indices of mice treated with HU daily for ~1 sperm cycle (2 months) were compared with those of their control counterparts. All indices of fertility were significantly reduced among mice treated with HU compared to controls. Interestingly, significant improvements in fertility indices were apparent after a 4-month withdrawal from HU treatment (testis weight: month 1 post-HU withdrawal (M1): HU, 0.09 ± 0.01 vs. control, 0.33 ± 0.03; M4: HU, 0.26 ± 0.03 vs. control, 0.37 ± 0.04 g); sperm motility (M1: HU,12 vs. 59; M4: HU, 45 vs. control, 61%; sperm density (M1: HU, 1.3 ± 0.3 vs. control, 15.7 ± 0.9; M4: HU, 8.1 ± 2.5 vs. control, 16.8 ± 1.9 million). Further, circulating testosterone increased in the 4th month following HU withdrawal and was comparable to that of controls. When a mating experiment was conducted, recovering males sired viable offspring with untreated females albeit at a lower rate than control males (p < 0.05); therefore, qualifying HU as a potential candidate for male contraception.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/24/11/9374; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms24119374
URL الوصول: https://doaj.org/article/087d18d3e5964dc2b0d472e612e74855
رقم الأكسشن: edsdoj.087d18d3e5964dc2b0d472e612e74855
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms24119374