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Efficiency of Protective Interventions on Irinotecan-Induced Diarrhea: A Systematic Review and Meta-Analysis

التفاصيل البيبلوغرافية
العنوان: Efficiency of Protective Interventions on Irinotecan-Induced Diarrhea: A Systematic Review and Meta-Analysis
المؤلفون: Yanxi He MB, Lili Wu MM, Xiaoyi Qi MD,PhD, Xuan Wang MM, Bing He BS, Wei Zhang MM, Wenjing Zhao MB, Mingming Deng MB, Xia Xiong MB, Yu Wang MB, Sicheng Liang PhD
المصدر: Integrative Cancer Therapies, Vol 23 (2024)
بيانات النشر: SAGE Publishing, 2024.
سنة النشر: 2024
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background: Irinotecan is widely used in the treatment of various solid tumors, but the adverse effects from it, especially diarrhea, limit its use. Several clinical trials of prophylactic treatment of irinotecan-induced diarrhea (IID) have been ongoing, and some of the data are controversial. This encouraged us to conduct a meta-analysis of the effects of interventions on preventing IID. Method: This systematic review was conducted based on the PRISMA statement. We performed literature searches from PubMed, Web of Science, Embase, and Cochrane Library. The number registered in PROSPERO is CRD42022368633. After searching 1034 articles in the database and references, 8 studies were included in this meta-analysis. Result: The RR of high-grade diarrhea and all-grade diarrhea were 0.31 ( I 2 = 51%, 95% CI: 0.14-0.69; P = .004) and .76 ( I 2 = 65%, 95% CI: 0.62-0.93; P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1552-695X
15347354
Relation: https://doaj.org/toc/1552-695X
DOI: 10.1177/15347354241242110
URL الوصول: https://doaj.org/article/0890d19bb02a467b91152579d92225a2
رقم الأكسشن: edsdoj.0890d19bb02a467b91152579d92225a2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1552695X
15347354
DOI:10.1177/15347354241242110