دورية أكاديمية
Pathogenetic therapy of vascular-platelet hemostasis disorders in canine acute spontaneous babesiosis
| العنوان: | Pathogenetic therapy of vascular-platelet hemostasis disorders in canine acute spontaneous babesiosis |
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| المؤلفون: | O. A. Dubova, A. O. Rudchenko, D. V. Feshchenko, A. A. Dubovyi, I. V. Chala, O. A. Zghozinska |
| المصدر: | Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, Vol 23, Iss 103, Pp 96-102 (2021) |
| بيانات النشر: | Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | babesiosis, vascular-platelet hemostasis, rheosorbylact, dipyridamole, infusions, thrombocytopenia, circu-lating blood volume deficit, platelet aggregation, shock, dic syndrome, Veterinary medicine, SF600-1100 |
| الوصف: | The article presents the results of a study of the vascular-platelet hemostasis disorders processes in complications of canine acute spontaneous babesiosis, as well as a clinical trial of plasma substitute infusion for the purpose of identified disorders pathogenetic therapy. It was found that acute spontaneous Babesiosis is accompanied by complications in the form of subcompensated shock and a thrombogenic link of disseminated intravascular coagulation syndrome (DIC). This determines the potential risk of complications with a cautious prognosis. The basis for the diagnosis of complications is the establishment of the following changes: a significant deficit in the volume of circulating blood (a decrease in the hematocrit value, the volume of circulating plasma, the volume of circulating red blood cells, the specific volume of circulating blood), as well as significant changes in the functioning of the vascular-platelet link of hemostasis – thrombocytopenia against the background of an increase in the spontaneous aggregation ability of platelets and red blood cells, an increase in the wetting index of the vascular wall, which determines the thrombogenic state, and pronounced thrombocytopenia indicates the consumption of these shaped elements in blood clots. The described changes indicate the development of subcompensated shock and the thrombogenic component of DIC syndrome. Given the prognostic danger of established complications, there is a need for pathogenetic therapy of severe conditions. Infusions of plasma substitute solutions have been proposed to eliminate shock phenomena and the thrombogenic state of disseminated intravascular coagulation syndrome. A clinical trial of intravenous administration of Rheosorbylact solution and a mixture of Rheosorbylact with Dipyridamole was conducted in a comparative aspect. It is shown that a mixture of Rheosorbylact 100 ml and Dipyridamole solution 0.5 % 4 ml in the form of infusions at a dose of 5 ml/kg of animal body weight per day for 3 days can bring hemodynamic parameters and parameters of vascular-platelet hemostasis to physiological ones within 48 hours compared to an infusion of Rheosorbylact solution in its pure form. The synergy of the crystalloid solution of Rheosorbylact and the disaggregating vasodilator Dipyridamole enhances the disaggregating effect of both drugs, and the crystalloid solution itself is able to restore the lost volume of circulating blood. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian Ukrainian |
| تدمد: | 2518-7554 2518-1327 |
| Relation: | https://nvlvet.com.ua/index.php/journal/article/view/4205; https://doaj.org/toc/2518-7554; https://doaj.org/toc/2518-1327 |
| DOI: | 10.32718/nvlvet10313 |
| URL الوصول: | https://doaj.org/article/08d2cf8fbc514601b7cbffedba163368 |
| رقم الأكسشن: | edsdoj.08d2cf8fbc514601b7cbffedba163368 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25187554 25181327 |
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| DOI: | 10.32718/nvlvet10313 |