دورية أكاديمية
Sarcoidosis and Airway Disease After Immune Checkpoint Inhibitor Therapy: Case Study and Review of the Literature
| العنوان: | Sarcoidosis and Airway Disease After Immune Checkpoint Inhibitor Therapy: Case Study and Review of the Literature |
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| المؤلفون: | Felipe Soto, Luis F. Torre-Sada, Frank E. Mott, Sang T. Kim, Roza Nurieva, Vickie R. Shannon, Saadia A. Faiz, Roberto F. Casal, Mehmet Altan, Julie Lin, Ajay Sheshadri |
| المصدر: | Journal of Immunotherapy and Precision Oncology, Vol 6, Iss 2, Pp 111-116 (2023) |
| بيانات النشر: | Innovative Healthcare Institute, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | immune checkpoint inhibitor, sarcoidosis, severe asthma, eosinophilia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Pulmonary toxicity from immune checkpoint inhibitor therapy is typically a severe and potentially fatal complication, but these observations are driven by the most common toxicity, pneumonitis. Rarer pulmonary immune related adverse events, like airway disease and sarcoidosis, may have a more benign course. In this case report, we present a patient in whom therapy with the PD-1 inhibitor pembrolizumab resulted in severe eosinophilic asthma and sarcoidosis. This is the first case showing that anti–IL-5 inhibition may be safe in patients who develop eosinophilic asthma after ICI therapy. We further show that sarcoidosis does not necessarily require treatment cessation. This case highlights relevant nuances when clinicians face pulmonary toxicities other than pneumonitis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2666-2345 2590-017X |
| Relation: | https://doaj.org/toc/2666-2345; https://doaj.org/toc/2590-017X |
| DOI: | 10.36401/JIPO-22-30 |
| URL الوصول: | https://doaj.org/article/08e33367ec8941b89b5f916d90167269 |
| رقم الأكسشن: | edsdoj.08e33367ec8941b89b5f916d90167269 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26662345 2590017X |
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| DOI: | 10.36401/JIPO-22-30 |