دورية أكاديمية
Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy lossResearch in context
| العنوان: | Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy lossResearch in context |
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| المؤلفون: | Mingming Yu, Guizhen Du, Qiaoqiao Xu, Zhenyao Huang, Xiaomin Huang, Yufeng Qin, Li Han, Yun Fan, Yan Zhang, Xiumei Han, Ziyan Jiang, Yankai Xia, Xinru Wang, Chuncheng Lu |
| المصدر: | EBioMedicine, Vol 35, Iss , Pp 334-344 (2018) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine, Medicine (General), R5-920 |
| الوصف: | Background: Aberrant DNA methylation is considered to be a potential cause of recurrent pregnancy loss (RPL), while potential mechanism has not yet been elucidated. Methods: In order to uncover the contribution of the perturbation of DNA methylation in RPL, we performed genome-wide DNA methylation analysis combined with genome-wide gene expression in decidua tissue. Findings: Totally, 539 differentially methylated regions (DMRs) were identified and significantly correlated with gene expressions. We observed that hypo-methylated DMR near CREB5 recruited transcription factors binding, such as P53 and SP1, and in turn upregulated CREB5. Compromised cell migration and apoptosis were observed in human CREB5 overexpression trophoblast cell lines, indicating dysfunctional trophoblast cells might contribute to RPL after hypo-methylation of CREB5. In addition, overexpression of CREB5 altered cell cycle. Interpretation: Our data highlights a role of CREB5 involved in the pathogenesis of RPL, and CREB5 maybe a potential diagnostic biomarker for RPL. Keywords: Recurrent pregnancy loss, DNA methylation, Gene expression, CREB5 |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396418302846; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2018.07.042 |
| URL الوصول: | https://doaj.org/article/0925c9ae5a954e599c089f6d3d89b8ac |
| رقم الأكسشن: | edsdoj.0925c9ae5a954e599c089f6d3d89b8ac |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2018.07.042 |