دورية أكاديمية
Additive and nonadditive effects of salmon calcitonin and omega-3 fatty acids on antioxidant, hematological and bone and cartilage markers in experimental diabetic-osteoarthritic rats
| العنوان: | Additive and nonadditive effects of salmon calcitonin and omega-3 fatty acids on antioxidant, hematological and bone and cartilage markers in experimental diabetic-osteoarthritic rats |
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| المؤلفون: | Wale J Adeyemi, Luqman A Olayaki |
| المصدر: | Chinese Journal of Physiology, Vol 62, Iss 3, Pp 108-116 (2019) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Physiology |
| مصطلحات موضوعية: | calcitonin, diabetes, omega-3 fatty acids, osteoarthritis, Physiology, QP1-981 |
| الوصف: | Reports on the coexistence of diabetes mellitus and osteoarthritis in human subjects dated back to the 1960s. However, there is no account in literature on the co-manifestation of these disease conditions in experimental animals. In our previous study, we reported for the first time, the effects of pharmacological agents on glucoregulatory indices, lipid profile, and inflammatory markers in experimental diabetic-knee osteoarthritic rat. However, in the present study, the effects of salmon calcitonin (Sct), and/or omega-3 fatty acids (N-3) were further investigated on other biomarkers. Forty-nine rats of seven animals per group were used for this study. Diabetes was induced by the administration of streptozotocin (65 mg/kg) and nicotinamide (110 mg/kg). Thereafter, knee osteoarthritis was induced by the intra-articular injection of 4 mg of sodium monoiodoacetate in 40 μl of saline. Nine days after the inductions, treatments started, and they lasted for 4 weeks. N-3 was administered at 200 mg/kg/day, while Sct was administered at 2.5 and 5.0 IU/kg/day. The results of the study indicated that the induced diabetes-knee osteoarthritis caused significant alterations in all the observed biomarkers. Sct showed a dose-specific effect and an additive action with N-3 in reducing malondialdehyde and lactate dehydrogenase, and in elevating total bilirubin and total antioxidant capacity. However, it largely demonstrated a nondose-specific effect and nonadditive action with N-3 on superoxide dismutase, catalase, glutathione peroxidase, total alkaline phosphatase, c-telopeptide of type-I collagen, collagen type-2 alpha 1, and hematological indices. In conclusion, the combined administration of Sct and N-3 proffer better therapeutic effects than the single therapy; therefore, they could be used in the management of diabetic-osteoarthritic condition. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0304-4920 2666-0059 72246049 |
| Relation: | http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2019;volume=62;issue=3;spage=108;epage=116;aulast=Adeyemi; https://doaj.org/toc/0304-4920; https://doaj.org/toc/2666-0059 |
| DOI: | 10.4103/CJP.CJP_8_18 |
| URL الوصول: | https://doaj.org/article/097ebf7224604938803d9835c7c88a79 |
| رقم الأكسشن: | edsdoj.097ebf7224604938803d9835c7c88a79 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03044920 26660059 72246049 |
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| DOI: | 10.4103/CJP.CJP_8_18 |