دورية أكاديمية
أعرض في EDS

HIVToolbox, an integrated web application for investigating HIV.

التفاصيل البيبلوغرافية
العنوان: HIVToolbox, an integrated web application for investigating HIV.
المؤلفون: David Sargeant, Sandeep Deverasetty, Yang Luo, Angel Villahoz Baleta, Stephanie Zobrist, Viraj Rathnayake, Jacqueline C Russo, Jay Vyas, Mark A Muesing, Martin R Schiller
المصدر: PLoS ONE, Vol 6, Iss 5, p e20122 (2011)
بيانات النشر: Public Library of Science (PLoS), 2011.
سنة النشر: 2011
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Many bioinformatic databases and applications focus on a limited domain of knowledge federating links to information in other databases. This segregated data structure likely limits our ability to investigate and understand complex biological systems. To facilitate research, therefore, we have built HIVToolbox, which integrates much of the knowledge about HIV proteins and allows virologists and structural biologists to access sequence, structure, and functional relationships in an intuitive web application. HIV-1 integrase protein was used as a case study to show the utility of this application. We show how data integration facilitates identification of new questions and hypotheses much more rapid and convenient than current approaches using isolated repositories. Several new hypotheses for integrase were created as an example, and we experimentally confirmed a predicted CK2 phosphorylation site. Weblink: [http://hivtoolbox.bio-toolkit.com].
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3102074?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0020122
URL الوصول: https://doaj.org/article/d0995748f76b414f9cce7fed833898f4
رقم الأكسشن: edsdoj.0995748f76b414f9cce7fed833898f4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0020122