دورية أكاديمية
Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus
| العنوان: | Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus |
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| المؤلفون: | Natália S. Dias, Antônio L. Teixeira, Breno S. Diniz, Erica L. Vieira, Bernardo de M. Viana, Izabela G. Barbosa |
| المصدر: | Trends in Psychiatry and Psychotherapy, Vol 46 (2024) |
| بيانات النشر: | Associação de Psiquiatria do Rio Grande do Sul, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Psychiatry |
| مصطلحات موضوعية: | Female, cytokines, inflammation, major depressive disorder, diabetes mellitus, elderly, Psychiatry, RC435-571 |
| الوصف: | Abstract Objective This study aimed at investigating a set of peripheral cytokines in elderly female patients with MDD, comparing them to controls, and assessing the potential influence of clinical comorbidities on inflammatory markers. Methods Twenty-five elderly female patients diagnosed with MDD and 19 age-matched female controls were enrolled on this study. Plasma levels of interleukin (IL)-4, IL-6, IL-10, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were evaluated with commercially-available assays. Results Elderly female patients with MDD exhibited higher plasma IL-6 and IL-4 levels when compared to controls. In a logistic regression model taking cytokine levels, comorbidities, and age into account, only type 2 diabetes mellitus (DM2) remained associated with MDD. Conclusion Diabetes influences the association between MDD and higher levels of cytokines in elderly female patients. Future studies should take this evidence into account in order to mitigate confounding factors. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian Portuguese |
| تدمد: | 2238-0019 2237-6089 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2237-60892024000100700&tlng=en; https://doaj.org/toc/2238-0019 |
| DOI: | 10.47626/2237-6089-2022-0466 |
| URL الوصول: | https://doaj.org/article/09a2312a0d3b452981153cacdd51dee7 |
| رقم الأكسشن: | edsdoj.09a2312a0d3b452981153cacdd51dee7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22380019 22376089 |
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| DOI: | 10.47626/2237-6089-2022-0466 |