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Comparative evaluation of four hydrogen peroxide-based systems to decontaminate N95 respirators

التفاصيل البيبلوغرافية
العنوان: Comparative evaluation of four hydrogen peroxide-based systems to decontaminate N95 respirators
المؤلفون: Shawn Clark, Herman Ng, Ge Wu, Devika Jain, Garry Bassi, Rita Kandel, Tony Mazzulli
المصدر: Antimicrobial Stewardship & Healthcare Epidemiology, Vol 1 (2021)
بيانات النشر: Cambridge University Press, 2021.
سنة النشر: 2021
المجموعة: LCC:Infectious and parasitic diseases
LCC:Public aspects of medicine
مصطلحات موضوعية: Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
الوصف: Abstract Objective: Protocols designed to facilitate N95 filtering facepiece respirator (FFR) decontamination by commercial sterilization devices do not recommend that operators verify the device’s performance against pathogens deposited on FFRs. Here, we compared the treatment efficacy of 4 hydrogen peroxide-based systems that were authorized for N95 decontamination during the COVID-19 pandemic. Methods: Suspensions prepared from S. aureus ATCC 29213 and 44300, B. subtilis ATCC 6633, a vancomycin-resistant E. faecium isolate (VRE), E. coli ATCC 25922, and P. aeruginosa ATCC 27853 colonies were inoculated onto nine 1-cm2 areas on a 3M 1805, 1860, 1860S, 1870+, 8210, 8110S, or 9105S FFR. Contaminated respirators were treated according to protocols recommended by the STERRAD 100NX, Bioquell Z-2, Sterizone VP4, or Clēan Works Mini systems. Decontamination efficacy was determined by comparing colony counts cultured from excised segments of treated and untreated FFR. Results: All devices achieved a 6-log reduction in bacterial burden and met FDA sterilization criteria. The Bioquell Z-2 device demonstrated 100% efficacy against both gram-positive and gram-negative organisms with all FFRs tested. Colonies of S. aureus ATCC 29213 and 44300 and VRE were cultivable from up to 9 (100%) of 9 STERRAD 100NX– and Sterizone VP4–treated segments. Viable B. subtilis ATCC 6633 organisms were recovered from 76.0% of STERRAD 100NX–treated FFR segments. Conclusions: Variability in decontamination efficacy was noted across devices and FFR types. gram-positive organisms were more difficult to completely eliminate than were gram-negative organisms. Prior to initiating FFR decontamination practices, institutions should verify the effectiveness of their devices and the safety of treated FFR.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2732-494X
Relation: https://www.cambridge.org/core/product/identifier/S2732494X21001832/type/journal_article; https://doaj.org/toc/2732-494X
DOI: 10.1017/ash.2021.183
URL الوصول: https://doaj.org/article/09a2fdb055804e629a5b886def07aaa5
رقم الأكسشن: edsdoj.09a2fdb055804e629a5b886def07aaa5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2732494X
DOI:10.1017/ash.2021.183