دورية أكاديمية
أعرض في EDS

Elevated procoagulant endothelial and tissue factor expressing microparticles in women with recurrent pregnancy loss.

التفاصيل البيبلوغرافية
العنوان: Elevated procoagulant endothelial and tissue factor expressing microparticles in women with recurrent pregnancy loss.
المؤلفون: Rucha Patil, Kanjaksha Ghosh, Purnima Satoskar, Shrimati Shetty
المصدر: PLoS ONE, Vol 8, Iss 11, p e81407 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND: 15% of reproducing couples suffer from pregnancy loss(PL) and recurs in 2-3%. One of the most frequently hypothesized causes of unexplained PL refers to a defective maternal haemostatic response leading to uteroplacental thrombosis. Hereditary thrombophilia and antiphospholipid antibodies have been extensively described as risk factors for PL in women with unknown aetiology. Recently, a new marker has emerged: the cell-derived procoagulant circulating microparticles(MPs) which have been reported to have a major role in many thrombosis complicated diseases. This study aims to analyze the significance of procoagulant MPs in women suffering from unexplained recurrent pregnancy loss(RPL), and characterize their cellular origin. METHOD AND FINDINGS: 115 women with RPL were analyzed for common thrombophilia markers and different cell derived MPs-total annexinV, platelet(CD41a), endothelial(CD146,CD62e), leukocyte(CD45), erythrocyte(CD235a) and tissue factor(CD142)(TF) expressing MPs and were compared with 20 healthy non-pregnant women. Methodology for MP analysis was standardized by participating in the "Vascular Biology Scientific and Standardization Committee workshop". RESULTS: Total annexinV, TF and endothelial MPs were found significantly increased(p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3835417?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0081407
URL الوصول: https://doaj.org/article/09e47dbc9025472a9120b9d7877a3240
رقم الأكسشن: edsdoj.09e47dbc9025472a9120b9d7877a3240
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0081407