دورية أكاديمية
Case Series: Abscopal Benefit of Surgery in 3 Immunotherapy-Treated Patients With Unresectable Cancer
| العنوان: | Case Series: Abscopal Benefit of Surgery in 3 Immunotherapy-Treated Patients With Unresectable Cancer |
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| المؤلفون: | Bryan Oronsky MD, Chris Larson MD, PhD, Tony R. Reid MD, PhD, Corey A. Carter MD |
| المصدر: | Journal of Investigative Medicine High Impact Case Reports, Vol 6 (2018) |
| بيانات النشر: | SAGE Publishing, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine (General) LCC:Pathology |
| مصطلحات موضوعية: | Medicine (General), R5-920, Pathology, RB1-214 |
| الوصف: | For all of the optimism that immunotherapy has engendered, the flip side is that 7/10 patients with susceptible tumor types do not respond, while in nonsusceptible tumor types the response rates are significantly lower. In contradiction of the current orthodoxy against surgery in the setting of unresectable disease, we present 3 examples of immunotherapy-treated patients with widespread recurrence who experienced dramatic clinical improvement following debulking/metastasectomy. Taken together with examples from the literature that correlate longer survival with surgical intervention during treatment with immunotherapy, these 3 cases suggest that a new paradigm involving a wider role for surgery in the management of these patients should be explored. Possible mechanisms by which surgery may synergize with immunotherapy and improve outcomes are also discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2324-7096 23247096 |
| Relation: | https://doaj.org/toc/2324-7096 |
| DOI: | 10.1177/2324709618786319 |
| URL الوصول: | https://doaj.org/article/c0a2b16b54d143df8cdc4597f0472f21 |
| رقم الأكسشن: | edsdoj.0a2b16b54d143df8cdc4597f0472f21 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23247096 |
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| DOI: | 10.1177/2324709618786319 |