دورية أكاديمية
The CXCL12 Crossroads in Cancer Stem Cells and Their Niche
| العنوان: | The CXCL12 Crossroads in Cancer Stem Cells and Their Niche |
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| المؤلفون: | Juan Carlos López-Gil, Laura Martin-Hijano, Patrick C. Hermann, Bruno Sainz |
| المصدر: | Cancers, Vol 13, Iss 3, p 469 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | cancer stem cells, CSC niche, CXCL12, CXCR4, CXCR4 inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Cancer stem cells (CSCs) are defined as a subpopulation of “stem”-like cells within the tumor with unique characteristics that allow them to maintain tumor growth, escape standard anti-tumor therapies and drive subsequent repopulation of the tumor. This is the result of their intrinsic “stem”-like features and the strong driving influence of the CSC niche, a subcompartment within the tumor microenvironment that includes a diverse group of cells focused on maintaining and supporting the CSC. CXCL12 is a chemokine that plays a crucial role in hematopoietic stem cell support and has been extensively reported to be involved in several cancer-related processes. In this review, we will provide the latest evidence about the interactions between CSC niche-derived CXCL12 and its receptors—CXCR4 and CXCR7—present on CSC populations across different tumor entities. The interactions facilitated by CXCL12/CXCR4/CXCR7 axes seem to be strongly linked to CSC “stem”-like features, tumor progression, and metastasis promotion. Altogether, this suggests a role for CXCL12 and its receptors in the maintenance of CSCs and the components of their niche. Moreover, we will also provide an update of the therapeutic options being currently tested to disrupt the CXCL12 axes in order to target, directly or indirectly, the CSC subpopulation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13030469 2072-6694 |
| Relation: | https://www.mdpi.com/2072-6694/13/3/469; https://doaj.org/toc/2072-6694 |
| DOI: | 10.3390/cancers13030469 |
| URL الوصول: | https://doaj.org/article/0a2eec0ed5ff4cf180b1f8326b7efa78 |
| رقم الأكسشن: | edsdoj.0a2eec0ed5ff4cf180b1f8326b7efa78 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13030469 20726694 |
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| DOI: | 10.3390/cancers13030469 |