دورية أكاديمية
Calcium channels and iron metabolism: A redox catastrophe in Parkinson's disease and an innovative path to novel therapies?
| العنوان: | Calcium channels and iron metabolism: A redox catastrophe in Parkinson's disease and an innovative path to novel therapies? |
|---|---|
| المؤلفون: | Matthew K. Boag, Linlin Ma, George D. Mellick, Dean L. Pountney, Yunjiang Feng, Ronald J. Quinn, Alan Wee-Chung Liew, Mahendiran Dharmasivam, Mahan Gholam Azad, Rizwana Afroz, Des R. Richardson |
| المصدر: | Redox Biology, Vol 47, Iss , Pp 102136- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Iron, Iron-loading, Iron transport, Iron redox cycling, Iron dyshomeostasis, Parkinson's disease, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Autonomously spiking dopaminergic neurons of the substantia nigra pars compacta (SNpc) are exquisitely specialized and suffer toxic iron-loading in Parkinson's disease (PD). However, the molecular mechanism involved remains unclear and critical to decipher for designing new PD therapeutics. The long-lasting (L-type) CaV1.3 voltage-gated calcium channel is expressed at high levels amongst nigral neurons of the SNpc, and due to its role in calcium and iron influx, could play a role in the pathogenesis of PD. Neuronal iron uptake via this route could be unregulated under the pathological setting of PD and potentiate cellular stress due to its redox activity. This Commentary will focus on the role of the CaV1.3 channels in calcium and iron uptake in the context of pharmacological targeting. Prospectively, the audacious use of artificial intelligence to design innovative CaV1.3 channel inhibitors could lead to breakthrough pharmaceuticals that attenuate calcium and iron entry to ameliorate PD pathology. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-2317 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213231721002950; https://doaj.org/toc/2213-2317 |
| DOI: | 10.1016/j.redox.2021.102136 |
| URL الوصول: | https://doaj.org/article/0a4d3dd63b704e99bab121ccde7b7f52 |
| رقم الأكسشن: | edsdoj.0a4d3dd63b704e99bab121ccde7b7f52 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22132317 |
|---|---|
| DOI: | 10.1016/j.redox.2021.102136 |