دورية أكاديمية
In Vivo Monitoring of the Antiangiogenic Effect of Neurotensin Receptor-Mediated Radiotherapy by Small-Animal Positron Emission Tomography: A Pilot Study
| العنوان: | In Vivo Monitoring of the Antiangiogenic Effect of Neurotensin Receptor-Mediated Radiotherapy by Small-Animal Positron Emission Tomography: A Pilot Study |
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| المؤلفون: | Simone Maschauer, Tina Ruckdeschel, Philipp Tripal, Roland Haubner, Jürgen Einsiedel, Harald Hübner, Peter Gmeiner, Torsten Kuwert, Olaf Prante |
| المصدر: | Pharmaceuticals, Vol 7, Iss 4, Pp 464-481 (2014) |
| بيانات النشر: | MDPI AG, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | neurotensin receptor, positron emission tomography, radiotherapy, lutetium-177, RGD peptide, angiogenesis, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | The neurotensin receptor (NTS1) has emerged as an interesting target for molecular imaging and radiotherapy of NTS-positive tumors due to the overexpression in a range of tumors. The aim of this study was to develop a 177Lu-labeled NTS1 radioligand, its application for radiotherapy in a preclinical model and the imaging of therapy success by small-animal positron emission tomography (µPET) using [68Ga]DOTA-RGD as a specific tracer for imaging angiogenesis. The 177Lu-labeled peptide was subjected to studies on HT29-tumor-bearing nude mice in vivo, defining four groups of animals (single dose, two fractionated doses, four fractionated doses and sham-treated animals). Body weight and tumor diameters were determined three times per week. Up to day 28 after treatment, µPET studies were performed with [68Ga]DOTA-RGD. At days 7–10 after treatment with four fractionated doses of 11–14 MBq (each at days 0, 3, 6 and 10), the tumor growth was slightly decreased in comparison with untreated animals. Using a single high dose of 51 MBq, a significantly decreased tumor diameter of about 50% was observed with the beginning of treatment. Our preliminary PET imaging data suggested decreased tumor uptake values of [68Ga]DOTA-RGD in treated animals compared to controls at day 7 after treatment. This pilot study suggests that early PET imaging with [68Ga]DOTA-RGD in radiotherapy studies to monitor integrin expression could be a promising tool to predict therapy success in vivo. Further successive PET experiments are needed to confirm the significance and predictive value of RGD-PET for NTS-mediated radiotherapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| Relation: | http://www.mdpi.com/1424-8247/7/4/464; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph7040464 |
| URL الوصول: | https://doaj.org/article/dd0a545755b14bdda5acc42681b1c929 |
| رقم الأكسشن: | edsdoj.0a545755b14bdda5acc42681b1c929 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph7040464 |