دورية أكاديمية
B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses
| العنوان: | B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses |
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| المؤلفون: | Ke Lin, Yawen Zhou, Jingwen Ai, Yan A. Wang, Senxin Zhang, Chao Qiu, Chaoyang Lian, Bo Gao, Tingting Liu, Hongyu Wang, Haocheng Zhang, Yi Zhang, Zhangfan Fu, Dan Li, Ning Jiang, Jingxin Guo, Jing Wu, Yan O. Wang, Shusen Song, Qiang Li, Yanan Yin, Jia Xia, Yingjie Xu, Leng-Siew Yeap, Xiaoqi Zheng, Ye Gu, Hongyan Liu, Wenhong Zhang, Fei-Long Meng |
| المصدر: | Emerging Microbes and Infections, Vol 11, Iss 1, Pp 452-464 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| مصطلحات موضوعية: | sars-cov-2, covid-19, b cell receptor, inactivated vaccine, antibody response, class switch recombination, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| الوصف: | Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those with strong antibody responses achieve sterilizing immunity. Thus far, biomarkers associated with levels of vaccine-elicited antibody response are still lacking. Here, we studied the antibody response of age- and gender-controlled healthy cohort, who received inactivated SARS-CoV-2 vaccines and profiled the B cell receptor repertoires in longitudinally consecutive samples. Upon vaccination, all vaccinated individuals displayed a convergent antibody response with shared common antibody clones and public neutralizing antibodies. Strikingly, poor vaccine-responders are distinguishable from strong vaccine-responders by a biased V-usage before vaccination and IgG to IgM mRNA ratio. These findings reveal molecular signatures associated with the different levels of vaccine-induced antibody response, which could be further developed into biomarkers for the design of vaccination strategies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2222-1751 22221751 |
| Relation: | https://doaj.org/toc/2222-1751 |
| DOI: | 10.1080/22221751.2022.2030197 |
| URL الوصول: | https://doaj.org/article/e0a5868752774f5eb9ed54f821323588 |
| رقم الأكسشن: | edsdoj.0a5868752774f5eb9ed54f821323588 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 22221751 |
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| DOI: | 10.1080/22221751.2022.2030197 |