دورية أكاديمية
Features of Mycobacterium bovis Complete Genomes Belonging to 5 Different Lineages
| العنوان: | Features of Mycobacterium bovis Complete Genomes Belonging to 5 Different Lineages |
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| المؤلفون: | Ciriac Charles, Cyril Conde, Fabien Vorimore, Thierry Cochard, Lorraine Michelet, Maria Laura Boschiroli, Franck Biet |
| المصدر: | Microorganisms, Vol 11, Iss 1, p 177 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Mycobacterium bovis, mammalian tuberculosis (TB), complete de novo assembly, transmission, pangenome, Biology (General), QH301-705.5 |
| الوصف: | Mammalian tuberculosis (TB) is a zoonotic disease mainly due to Mycobacterium bovis (M. bovis). A current challenge for its eradication is understanding its transmission within multi-host systems. Improvements in long-read sequencing technologies have made it possible to obtain complete bacterial genomes that provide a comprehensive view of species-specific genomic features. In the context of TB, new genomic references based on complete genomes genetically close to field strains are also essential to perform precise field molecular epidemiological studies. A total of 10 M. bovis strains representing each genetic lineage identified in France and in other countries were selected for performing complete assembly of their genomes. Pangenome analysis revealed a “closed” pangenome composed of 3900 core genes and only 96 accessory genes. Whole genomes-based alignment using progressive Mauve showed remarkable conservation of the genomic synteny except that the genomes have a variable number of copies of IS6110. Characteristic genomic traits of each lineage were identified through the discovery of specific indels. Altogether, these results provide new genetic features that improve the description of M. bovis lineages. The availability of new complete representative genomes of M. bovis will be useful to epidemiological studies and better understand the transmission of this clonal-evolving pathogen. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 11010177 2076-2607 |
| Relation: | https://www.mdpi.com/2076-2607/11/1/177; https://doaj.org/toc/2076-2607 |
| DOI: | 10.3390/microorganisms11010177 |
| URL الوصول: | https://doaj.org/article/0a638aff58c2425a9bdab359fd6240b3 |
| رقم الأكسشن: | edsdoj.0a638aff58c2425a9bdab359fd6240b3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11010177 20762607 |
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| DOI: | 10.3390/microorganisms11010177 |