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Metalloproteinases in Inflammatory Bowel Diseases

التفاصيل البيبلوغرافية
العنوان: Metalloproteinases in Inflammatory Bowel Diseases
المؤلفون: Marônek M, Marafini I, Gardlík R, Link R, Troncone E, Monteleone G
المصدر: Journal of Inflammation Research, Vol Volume 14, Pp 1029-1041 (2021)
بيانات النشر: Dove Medical Press, 2021.
سنة النشر: 2021
المجموعة: LCC:Pathology
LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: tissue inhibitor of metalloproteinases, crohn’s disease, ulcerative colitis, intestinal inflammation, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
الوصف: Martin Marônek,1,* Irene Marafini,2,* Roman Gardlík,1 René Link,3 Edoardo Troncone,2 Giovanni Monteleone2 1Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University in Bratislava, Bratislava, 81108, Slovakia; 2Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, 00133, Italy; 3Institute of Experimental Medicine, Faculty of Medicine, University of Pavol Jozef Šafárik, Košice, 040 11, Slovakia*These authors contributed equally to this workCorrespondence: Giovanni MonteleoneDipartimento di Medicina dei Sistemi, Università di Roma “Tor Vergata”, Via Montpellier 1, Rome, 00133, ItalyTel +39 06 20903702Fax +39 06 72596391Email Gi.Monteleone@Med.uniroma2.itAbstract: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the gastrointestinal tract, encompassing two main disorders: Crohn’s disease (CD) and ulcerative colitis (UC). In both these pathologies, excessive and local immune response against luminal antigens promotes a pathological process leading to various degrees of gut damage. Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. In physiological conditions, MMPs are produced at very low level and generally in the latent form and are involved in the normal tissue turnover. Their function is inhibited by tissue inhibitors of metalloproteinases (TIMPs). However, in inflamed tissue of IBD patients, MMPs are produced in excess and/or the activity of TIMPs is not sufficient to block MMPs, thereby making a major contribution to the IBD-related mucosal degradation. In this review, we summarize the available evidence on the expression and role of MMPs in IBD.Keywords: tissue inhibitor of metalloproteinases, Crohn’s disease, ulcerative colitis, intestinal inflammation
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1178-7031
13220284
Relation: https://www.dovepress.com/metalloproteinases-in-inflammatory-bowel-diseases-peer-reviewed-article-JIR; https://doaj.org/toc/1178-7031
URL الوصول: https://doaj.org/article/d0a7c1322028476daa88e1e76a36e3cf
رقم الأكسشن: edsdoj.0a7c1322028476daa88e1e76a36e3cf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11787031
13220284