دورية أكاديمية
أعرض في EDS

Durable response to durvalumab‐based immunochemotherapy in small‐cell lung carcinoma transformation from EGFR‐mutant non–small cell lung cancer: A case report

التفاصيل البيبلوغرافية
العنوان: Durable response to durvalumab‐based immunochemotherapy in small‐cell lung carcinoma transformation from EGFR‐mutant non–small cell lung cancer: A case report
المؤلفون: Yu‐Chung Li
المصدر: Thoracic Cancer, Vol 13, Iss 5, Pp 775-779 (2022)
بيانات النشر: Wiley, 2022.
سنة النشر: 2022
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: case reports, combined modality therapy, immunochemistry, immunotherapy, tumor biomarkers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Combined small‐cell lung carcinoma (C‐SCLC) is small‐cell lung carcinoma (SCLC) with added non–small‐cell morphology. We report a case of epidermal growth factor receptor (EGFR) mutation‐positive C‐SCLC in an 84‐year‐old patient with metastatic brain lesions who developed intrinsic resistance to osimertinib, a tyrosine kinase inhibitor (TKI). The patient was diagnosed with small‐cell transformation of non–small‐cell lung carcinoma (NSCLC) and received 6 cycles of dose‐adjusted durvalumab with etoposide and carboplatin. In December 2021, the patient received the seventeenth cycle of maintenance durvalumab 19 months after diagnosis and showed continued treatment response and disease control. Comprehensive molecular profiling and repeated biopsies are recommended in NSCLC patients who progress on first‐line EGFR‐TKIs. Durvalumab in combination with chemotherapy appears to be beneficial for EGFR mutation‐positive C‐SCLC patients that are resistant to TKIs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1759-7714
1759-7706
Relation: https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714
DOI: 10.1111/1759-7714.14325
URL الوصول: https://doaj.org/article/ad0a9d933cb84a97a95cf19ea347fabe
رقم الأكسشن: edsdoj.0a9d933cb84a97a95cf19ea347fabe
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17597714
17597706
DOI:10.1111/1759-7714.14325