دورية أكاديمية
Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure
العنوان: | Elevated Serum IgG Levels Positively Correlated with IL-27 May Indicate Poor Outcome in Patients with HBV-Related Acute-On-Chronic Liver Failure |
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المؤلفون: | Geng-lin Zhang, Qi-yi Zhao, Chan Xie, Liang Peng, Ting Zhang, Zhi-liang Gao |
المصدر: | Journal of Immunology Research, Vol 2019 (2019) |
بيانات النشر: | Wiley, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Immunologic diseases. Allergy |
مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607 |
الوصف: | Background and Aims. Serum immunoglobulins are frequently increased in patients with chronic liver disease, but little is known about the role of serum immunoglobulins and their correlations with interleukin-27 (IL-27) in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF). This study was aimed at determining the role of serum immunoglobulin (IgG, IgA, and IgM) levels and their associations with IL-27 in noncirrhotic patients with HBV-ACLF. Methods. Samples were assessed from thirty patients with HBV-ACLF, twenty-four chronic hepatitis B (CHB) subjects, and eighteen normal controls. Disease severity of HBV-ACLF was evaluated. Serum IL-27 levels were examined by enzyme-linked immunosorbent assay. Immunoglobulin levels were assessed using immunoturbidimetric assay. Correlations between immunoglobulin levels and IL-27 were analyzed. Receiver operating characteristic (ROC) curves were used to predict the 3-month mortality. Results. 25 (83.3%) HBV-ACLF patients had elevated serum IgG levels (>1 ULN), 14 (46.7%) patients had elevated IgA, and 15 (50%) had raised IgM. IgG, IgA, and IgM levels were higher in HBV-ACLF patients than in CHB patients and normal controls. Moreover, IgG, IgA, and IgM levels were positively correlated with Tbil levels but negatively correlated with prothrombin time activity (PTA) levels. Additionally, IgG levels were significantly increased in nonsurviving patients than in surviving HBV-ACLF patients (P=0.007) and positively correlated with MELD score (r=0.401, P=0.028). Also, IgG levels were positively correlated with IL-27 levels in HBV-ACLF patients (r=0.398, P=0.029). Furthermore, ROC curve showed that IgG levels could predict the 3-month mortality in HBV-ACLF patients (the area under the ROC curve: 0.752, P=0.005). Conclusions. Our findings demonstrated that serum immunoglobulins were preferentially elevated in HBV-ACLF patients. IgG levels were positively correlated with IL-27 and may predict prognosis in HBV-ACLF patients. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2314-8861 2314-7156 |
Relation: | https://doaj.org/toc/2314-8861; https://doaj.org/toc/2314-7156 |
DOI: | 10.1155/2019/1538439 |
URL الوصول: | https://doaj.org/article/0aba592d44a54058bde8ee88da95c94c |
رقم الأكسشن: | edsdoj.0aba592d44a54058bde8ee88da95c94c |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 23148861 23147156 |
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DOI: | 10.1155/2019/1538439 |