Uterine fibroids are the most common benign tumors of the uterus. They primarily occur in women aged 30-50 years old, rarely in adolescents. In this article, the diagnosis and treatment of a 16-year-old teenager with recurrent submucosal fibroids were reported. The patient underwent hysteroscopic myomectomy due to abnormal uterine bleeding （AUB）, whereas failed to receive postoperative follow-up on a regular basis. At 18 months after the operation, she was admitted to hospital again due to AUB. Transvaginal ultrasound detected a space-occupying mass of 5.2 cm×4.6 cm×3.8 cm in the uterine cavity. She repeatedly underwent hysteroscopic partial myomectomy. Postoperative pathological biopsy indicated the diagnosis of submucosal uterine fibroids. The diagnosis and treatment of this case suggests that in the diagnosis and treatment of recurrent uterine fibroids in adolescents, it is necessary to differentiate fibroids from sarcomatosis. Meantime, the patient’s fertility should be preserved to the largest extent and postoperative follow-up should be strengthened.
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