دورية أكاديمية
أعرض في EDS

Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis.
المؤلفون: Jinjia Chang, Xinyang Liu, Shanshan Wang, Zhe Zhang, Zheng Wu, Xiaowei Zhang, Jin Li
المصدر: PLoS ONE, Vol 9, Iss 8, p e105524 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Fibroblast growth factor receptor (FGFR) gene amplification has been reported in different types of cancer. We performed an up-to-date meta-analysis to further characterize the prognostic value of FGFR gene amplification in patients with cancer.A search of several databases, including MEDLINE (PubMed), EMBASE, Web of Science, and China National Knowledge Infrastructure, was conducted to identify studies examining the association between FGFR gene amplification and cancer. A total of 24 studies met the inclusion criteria, and overall incidence rates, hazard risk (HR), overall survival, disease-free survival, and 95% confidence intervals (CIs) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included studies.In the meta-analysis of 24 studies, the prevalence of FGFR gene amplification was FGFR1: 0.11 (95% CI: 0.08-0.13) and FGFR2: 0.04 (95% CI: 0.02-0.06). Overall survival was significantly worse among patients with FGFR gene amplification: FGFR1 [HR 1.57 (95% CI: 1.23-1.99); p = 0.0002] and FGFR2 [HR 2.27 (95% CI: 1.73-3.00); p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4149366?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0105524
URL الوصول: https://doaj.org/article/0b0c047b87c8486d899bc6f3aa51c9c7
رقم الأكسشن: edsdoj.0b0c047b87c8486d899bc6f3aa51c9c7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0105524