دورية أكاديمية
Quantitative glycomics monitoring of induced pluripotent- and embryonic stem cells during neuronal differentiation
| العنوان: | Quantitative glycomics monitoring of induced pluripotent- and embryonic stem cells during neuronal differentiation |
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| المؤلفون: | Michiyo Terashima, Maho Amano, Tomohiro Onodera, Shin-Ichiro Nishimura, Norimasa Iwasaki |
| المصدر: | Stem Cell Research, Vol 13, Iss 3, Pp 454-464 (2014) |
| بيانات النشر: | Elsevier, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Alterations in the structure of cell surface glycoforms occurring during the stages of stem cell differentiation remain unclear. We describe a rapid glycoblotting-based cellular glycomics method for quantitatively evaluating changes in glycoform expression and structure during neuronal differentiation of murine induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs). Our results show that changes in the expression of cellular N-glycans are comparable during the differentiation of iPSCs and ESCs. The expression of bisect-type N-glycans was significantly up-regulated in neurons that differentiated from both iPSCs and ESCs. From a glycobiological standpoint, iPSCs are an alternative neural cell source in addition to ESCs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1873-5061 1876-7753 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1873506114001160; https://doaj.org/toc/1873-5061; https://doaj.org/toc/1876-7753 |
| DOI: | 10.1016/j.scr.2014.10.006 |
| URL الوصول: | https://doaj.org/article/0b3d7eca4d774a43bb05625b68b27dec |
| رقم الأكسشن: | edsdoj.0b3d7eca4d774a43bb05625b68b27dec |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18735061 18767753 |
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| DOI: | 10.1016/j.scr.2014.10.006 |