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Spectrum of anti-NMDA receptor antibody encephalitis: Clinical profile, management and outcomes

التفاصيل البيبلوغرافية
العنوان: Spectrum of anti-NMDA receptor antibody encephalitis: Clinical profile, management and outcomes
المؤلفون: Amlan Kusum Datta, Alak Pandit, Samar Biswas, Atanu Biswas, Biman Kanti Roy, Goutam Gangopaddhyay
المصدر: Annals of Indian Academy of Neurology, Vol 24, Iss 3, Pp 383-389 (2021)
بيانات النشر: Wolters Kluwer Medknow Publications, 2021.
سنة النشر: 2021
المجموعة: LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: anti nmdar, autoimmune, encephalitis, immunotherapy, Neurology. Diseases of the nervous system, RC346-429
الوصف: Background: Anti-N-methyl D-aspartate receptor (anti NMDAR) antibody encephalitis is an immune-mediated entity characterised by a constellation of neuro-psychiatric symptoms. Objective: To describe clinical profile and treatment outcomes of patients with anti NMDAR antibody encephalitis. Settings and Design: Subjects were selected by screening for all patients satisfying Graus et al.'s criteria for probable anti NMDAR antibody encephalitis, admitted in neurology department of a tertiary care centre in Eastern India. Materials and Methods: A prospective, longitudinal study was conducted by identifying 25 patients with anti NMDAR antibodies in CSF and or serum, between September 2018 to February 2020. Statistical Analysis: Chi square test was used to compare variables. Results: Out of 98 patients screened, 25 subjects (14 females: 11 male) were positive for anti NMDAR autoantibodies, with a mean age of 17 years. 13 subjects belonged to paediatric age group. Most common presenting feature was memory/learning deficit (88%) followed by behavioural abnormalities (84%) and seizures (68%). 11 patients (44%) patients needed escalation to second line therapy, rituximab. Seven (28%) and twelve (48%) patients underwent complete (mRS 0-1) and partial recovery (mRS 2-3) respectively, while 4 (16%) became disabled (mRS 4-5). Mortality was 8%. Paediatric population had a better outcome in terms of disability (p = 0.043). Conclusion: Anti NMDAR-Ab encephalitis is the most common cause of antibody positive autoimmune encephalitis worldwide. There are important clinical markers and investigational profiles which carry prognostic significance.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0972-2327
1998-3549
Relation: http://www.annalsofian.org/article.asp?issn=0972-2327;year=2021;volume=24;issue=3;spage=383;epage=389;aulast=Datta; https://doaj.org/toc/0972-2327; https://doaj.org/toc/1998-3549
DOI: 10.4103/aian.AIAN_817_20
URL الوصول: https://doaj.org/article/0bea84d7e0b84eee8d00d6ecfbc0c247
رقم الأكسشن: edsdoj.0bea84d7e0b84eee8d00d6ecfbc0c247
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:09722327
19983549
DOI:10.4103/aian.AIAN_817_20