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Tandem Mass Spectrometry Detection of Quorum Sensing Activity in Multidrug Resistant Clinical Isolate Acinetobacter baumannii

التفاصيل البيبلوغرافية
العنوان: Tandem Mass Spectrometry Detection of Quorum Sensing Activity in Multidrug Resistant Clinical Isolate Acinetobacter baumannii
المؤلفون: Kok-Gan Chan, Huey Jia Cheng, Jian Woon Chen, Wai-Fong Yin, Yun Fong Ngeow
المصدر: The Scientific World Journal, Vol 2014 (2014)
بيانات النشر: Wiley, 2014.
سنة النشر: 2014
المجموعة: LCC:Technology
LCC:Medicine
LCC:Science
مصطلحات موضوعية: Technology, Medicine, Science
الوصف: Many Proteobacteria communicate via production followed by response of quorum sensing molecules, namely, N-acyl homoserine lactones (AHLs). These molecules consist of a lactone moiety with N-acyl side chain with various chain lengths and degrees of saturation at C-3 position. AHL-dependent QS is often associated with regulation of diverse bacterial phenotypes including the expression of virulence factors. With the use of biosensor and high resolution liquid chromatography tandem mass spectrometry, the AHL production of clinical isolate A. baumannii 4KT was studied. Production of short chain AHL, namely, N-hexanoyl-homoserine lactone (C6-HSL) and N-octanoyl-homoserine lactone (C8-HSL), was detected.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2356-6140
1537-744X
Relation: https://doaj.org/toc/2356-6140; https://doaj.org/toc/1537-744X
DOI: 10.1155/2014/891041
URL الوصول: https://doaj.org/article/0c0309ffb804409689708f8c6d238efc
رقم الأكسشن: edsdoj.0c0309ffb804409689708f8c6d238efc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23566140
1537744X
DOI:10.1155/2014/891041