دورية أكاديمية
The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder
| العنوان: | The Association Between Parkinson’s Disease and Attention-Deficit Hyperactivity Disorder |
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| المؤلفون: | Hueng-Chuen Fan, Yu-Kang Chang, Jeng-Dau Tsai, Kuo-Liang Chiang, Jui-Hu Shih, Kuan-Yi Yeh, Kuo-Hsing Ma, I-Hsun Li |
| المصدر: | Cell Transplantation, Vol 29 (2020) |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | While Parkinson’s disease (PD) and attention-deficit hyperactivity disorder (ADHD) are two distinct conditions, it has been hypothesized that they share several overlapping anatomical and neurochemical changes. In order to investigate that hypothesis, this study used claims data from Taiwan’s Longitudinal Health Insurance Database 2000 to provide the significant nationwide population-based evidence of an increased risk of PD among ADHD patients, and the connection between the two conditions was not the result of other comorbidities. Moreover, this study showed that the patients with PD were 2.8 times more likely to have a prior ADHD diagnosis compared with those without a prior history of ADHD. Furthermore, an animal model of ADHD was generated by neonatally injecting rats with 6-hydroxydopamine (6-OHDA). These rats were subjected to behavior tests and the 99mTc-TRODAT-1 brain imaging at the juvenile stage. Compared to control group rats, the 6-OHDA rats showed a significantly reduced specific uptake ratio in the striatum, indicating an underlying PD-linked pathology in the brains of these ADHD phenotype-expressing rats. Overall, these results support that ADHD shares a number of anatomical and neurochemical changes with PD. As such, improved knowledge of the neurochemical mechanisms underlying ADHD could result in improved treatments for various debilitating neurological disorders, including PD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1555-3892 09636897 |
| Relation: | https://doaj.org/toc/1555-3892 |
| DOI: | 10.1177/0963689720947416 |
| URL الوصول: | https://doaj.org/article/0c0c9c71fb24491a8df1f3eaf066981c |
| رقم الأكسشن: | edsdoj.0c0c9c71fb24491a8df1f3eaf066981c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15553892 09636897 |
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| DOI: | 10.1177/0963689720947416 |