دورية أكاديمية
Hormetic Effect of Berberine Attenuates the Anticancer Activity of Chemotherapeutic Agents.
العنوان: | Hormetic Effect of Berberine Attenuates the Anticancer Activity of Chemotherapeutic Agents. |
---|---|
المؤلفون: | Jiaolin Bao, Borong Huang, Lidi Zou, Shenghui Chen, Chao Zhang, Yulin Zhang, Meiwan Chen, Jian-Bo Wan, Huanxing Su, Yitao Wang, Chengwei He |
المصدر: | PLoS ONE, Vol 10, Iss 9, p e0139298 (2015) |
بيانات النشر: | Public Library of Science (PLoS), 2015. |
سنة النشر: | 2015 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | Hormesis is a phenomenon of biphasic dose response characterized by exhibiting stimulatory or beneficial effects at low doses and inhibitory or toxic effects at high doses. Increasing numbers of chemicals of various types have been shown to induce apparent hormetic effect on cancer cells. However, the underlying significance and mechanisms remain to be elucidated. Berberine, one of the major active components of Rhizoma coptidis, has been manifested with notable anticancer activities. This study aims to investigate the hormetic effect of berberine and its influence on the anticancer activities of chemotherapeutic agents. Our results demonstrated that berberine at low dose range (1.25 ~ 5 μM) promoted cell proliferation to 112% ~170% of the untreated control in various cancer cells, while berberine at high dose rage (10 ~ 80 μM) inhibited cell proliferation. Further, we observed that co-treatment with low dose berberine could significantly attenuate the anticancer activity of chemotherapeutic agents, including fluorouracil (5-FU), camptothecin (CPT), and paclitaxel (TAX). The hormetic effect and thereby the attenuated anticancer activity of chemotherapeutic drugs by berberine may attributable to the activated protective stress response in cancer cells triggered by berberine, as evidenced by up-regulated MAPK/ERK1/2 and PI3K/AKT signaling pathways. These results provided important information to understand the potential side effects of hormesis, and suggested cautious application of natural compounds and relevant herbs in adjuvant treatment of cancer. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1932-6203 |
Relation: | http://europepmc.org/articles/PMC4589364?pdf=render; https://doaj.org/toc/1932-6203 |
DOI: | 10.1371/journal.pone.0139298 |
URL الوصول: | https://doaj.org/article/0c14b65189f74b0cb0111121eafb194c |
رقم الأكسشن: | edsdoj.0c14b65189f74b0cb0111121eafb194c |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19326203 |
---|---|
DOI: | 10.1371/journal.pone.0139298 |