دورية أكاديمية
Effects of Tumor Necrosis Factor Alpha Blocker Adalimumab in Experimental Brain Injury
| العنوان: | Effects of Tumor Necrosis Factor Alpha Blocker Adalimumab in Experimental Brain Injury |
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| المؤلفون: | Mehmet Yalçın Günal, Seyda Cankaya, Sukru Burak Tonuk, Ekrem Musa Ozdemi̇r, Ayse Arzu Sayın Sakul |
| المصدر: | Acta Medica Alanya, Vol 3, Iss 3, Pp 306-310 (2019) |
| بيانات النشر: | Alanya Alaaddin Keykubat University, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | beyin hasarı, adalimumab, nöroprotektif etki, brain injury, neural protection, Medicine |
| الوصف: | Aim: We aimed to investigate the neuroprotective role of adalimumab based on the hypothesis that "TNF-alpha inhibitor Adalimumab may affect inflammation-related neuronal injury due to its anti-inflammatory effect". Methods: To investigate the effects of Adalimumab, we induced brain injury in mice using a cold trauma model and evaluated the underlying cell survival/ death mechanisms via cresyl violet and calculated infarct/edema volume with image analyze system. Results: Although our data indicated a tendency to decreased infarct and edema volume, these findings are not significant statistically. Conclusion: To the best of our knowledge, this is the first study evaluating the neuroprotective effect of Adalimumab on injured neurons. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Turkish |
| تدمد: | 2587-0319 |
| Relation: | https://dergipark.org.tr/en/pub/medalanya/issue/49795/632455?publisher=alku; https://doaj.org/toc/2587-0319 |
| DOI: | 10.30565/medalanya.632455 |
| URL الوصول: | https://doaj.org/article/0c3e6a3187974f40b993c2f1f977ddf1 |
| رقم الأكسشن: | edsdoj.0c3e6a3187974f40b993c2f1f977ddf1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25870319 |
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| DOI: | 10.30565/medalanya.632455 |