دورية أكاديمية
Efficient transplacental transfer of SARS-CoV-2 antibodies between naturally exposed mothers and infants in Accra, Ghana
| العنوان: | Efficient transplacental transfer of SARS-CoV-2 antibodies between naturally exposed mothers and infants in Accra, Ghana |
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| المؤلفون: | Frederica D. Partey, Dorotheah Obiri, Evelyn Yayra Bonney, Abigail Naa Adjorkor Pobee, Isaac Kumi Damptey, Keren Ennuson, Jayln Akwetea-Foli, Franklin Yengdem Nuokpem, David Courtin, Kwadwo A. Kusi, Benedicta A. Mensah |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | COVID-19, SARS-COV-2, Maternal COVID-19, Prenatal COVID-19 placental transfer, Transfer efficiency, Medicine, Science |
| الوصف: | Abstract We aimed to determine SARS-CoV-2 antibody seropositivity among pregnant women and the transplacental transfer efficiency of SARS-CoV-2-specific antibodies relative to malaria antibodies among SARS-CoV-2 seropositive mother-cord pairs. This cross-sectional study was conducted in Accra, Ghana, from March to May 2022. Antigen- specific IgG antibodies against SARS-CoV-2 (nucleoprotein and spike-receptor binding domain) and malarial antigens (circumsporozoite protein and merozoite surface protein 3) in maternal and cord plasma were measured by ELISA. Plasma from both vaccinated and unvaccinated pregnant women were tested for neutralizing antibodies using commercial kit. Of the unvaccinated pregnant women tested, 58.12% at antenatal clinics and 55.56% at the delivery wards were seropositive for both SARS-CoV-2 nucleoprotein and RBD antibodies. Anti-SARS-CoV-2 antibodies in cord samples correlated with maternal antibody levels (N antigen rs = 0.7155, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 59618043 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-61496-3 |
| URL الوصول: | https://doaj.org/article/0c635591b41e48c8bf4f59618043e1eb |
| رقم الأكسشن: | edsdoj.0c635591b41e48c8bf4f59618043e1eb |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 59618043 |
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| DOI: | 10.1038/s41598-024-61496-3 |