دورية أكاديمية
Cleavage of Early Mouse Embryo with Damaged DNA
| العنوان: | Cleavage of Early Mouse Embryo with Damaged DNA |
|---|---|
| المؤلفون: | Vladimír Baran, Jozef Pisko |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 7, p 3516 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | mouse embryogenesis, DNA damage, neocarzinostatin, γH2A.X, micronucleus, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The preimplantation period of embryogenesis is crucial during mammalian ontogenesis. During this period, the mitotic cycles are initiated, the embryonic genome is activated, and the primary differentiation of embryonic cells occurs. All cellular abnormalities occurring in this period are the primary cause of fetal developmental disorders. DNA damage is a serious cause of developmental failure. In the context of DNA damage response on the cellular level, we analyzed the course of embryogenesis and phenotypic changes during the cleavage of a preimplantation embryo. Our results document that DNA damage induced before the resumption of DNA synthesis in a zygote can significantly affect the preimplantation development of the embryo. This developmental ability is related to the level of the DNA damage. We showed that one-cell embryos can correct the first cleavage cycle despite low DNA damage and incomplete replication. It seems that the phenomenon creates a predisposition to a segregation disorder of condensed chromatin that results in the formation of micronuclei in the developmental stages following the first cleavage. We conclude that zygote tolerates a certain degree of DNA damage and considers its priority to complete the first cleavage stage and continue embryogenesis as far as possible. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/7/3516; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23073516 |
| URL الوصول: | https://doaj.org/article/d0ce0f5f39f1477486856ce7db53c0b1 |
| رقم الأكسشن: | edsdoj.0ce0f5f39f1477486856ce7db53c0b1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms23073516 |