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MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells

التفاصيل البيبلوغرافية
العنوان: MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells
المؤلفون: Hao-Liang Zhao, Hui-Yu Li, Yan-Zhang Tian, Shi-Ming Wang, Wen-Ting Yan, Yu-Xuan Wang, Hong-Yan Jia
المصدر: International Journal of Molecular Sciences, Vol 13, Iss 7, Pp 8762-8774 (2012)
بيانات النشر: MDPI AG, 2012.
سنة النشر: 2012
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: hepatocellular carcinoma, miR-125b, Mcl-1, IL6R, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: MicroRNAs (miRNAs) are important regulators of multiple cellular processes, and the deregulation of miRNA is a common event in diverse human diseases, particularly cancer. However, the mechanisms underlying the relationship between disordered miRNA expression and tumorigenesis have remained largely unknown. In this study, we demonstrated the down-regulation of miR-125b in hepatocellular carcinoma (HCC) tissues and HCC cell lines by Northern blot and quantitative RT-PCR analyses. The ectopic expression of miR-125b reduced the cellular proliferation and cell cycle progression of HCC cells by targeting Mcl-1 and IL6R. Furthermore, the miR-125b-induced inhibition of cell proliferation was rescued by the expression of Mcl-1 or IL6R variants that lacked 3' UTRs. Thus, this study revealed the differential expression of miR-125b in HCC cells and elucidated its potential as a tumor suppressor in HCC development.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: http://www.mdpi.com/1422-0067/13/7/8762; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms13078762
URL الوصول: https://doaj.org/article/0d340fb4992f4eadae302e2cdccdc39d
رقم الأكسشن: edsdoj.0d340fb4992f4eadae302e2cdccdc39d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms13078762