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Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy.

التفاصيل البيبلوغرافية
العنوان: Clinical significance of serum and mesangial galactose-deficient IgA1 in patients with IgA nephropathy.
المؤلفون: Yukihiro Wada, Kei Matsumoto, Taihei Suzuki, Tomohiro Saito, Nobuhiro Kanazawa, Shohei Tachibana, Ken Iseri, Motonori Sugiyama, Masayuki Iyoda, Takanori Shibata
المصدر: PLoS ONE, Vol 13, Iss 11, p e0206865 (2018)
بيانات النشر: Public Library of Science (PLoS), 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: INTRODUCTION:Galactose-deficient IgA1 (Gd-IgA1) is a critical pathogenic factor for IgA nephropathy (IgAN), but its value as a disease-specific biomarker remains controversial. We aimed to clarify the clinical significance of Gd-IgA1 in patients with IgAN. METHODS:We retrospectively reviewed 111 patients who were diagnosed with IgAN based on the findings of renal biopsies (RB) at Showa University Hospital since 2007. Serum Gd-IgA1 (s-Gd-IgA1) at the time of RB was compared among 111 IgAN patients, 18 Henoch-Schönlein purpura nephritis (HSPN) patients, 29 lupus nephritis (LN) patients, 28 ANCA-associated vasculitis (AAV) patients, and 13 minimal change disease (MCD) patients using ELISA with an anti-human Gd-IgA1-specific monoclonal antibody (KM55). We also immunohistochemically stained paraffin-embedded sections for mesangial Gd-IgA1 (m-Gd-IgA1) deposition using KM55. RESULTS:Although levels of s-Gd-IgA1 were comparable among IgAN and HSPN, s-Gd-IgA1 levels were significantly elevated in patients with IgAN compared with LN, AAV and MCD (IgAN vs. HSPN, LN, AAV, and MCD: 16.2 ± 9.1 vs. 14.2 ± 10.8, p = 0.263; 12.7 ± 9.4, p = 0.008; 13.1 ± 7.3, p = 0.059; and 8.2 ± 4.8 μg/mL, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC6214568?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0206865
URL الوصول: https://doaj.org/article/0d7cd08a1fe74e5d8ab587f2d92a5763
رقم الأكسشن: edsdoj.0d7cd08a1fe74e5d8ab587f2d92a5763
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0206865