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Association between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients.

التفاصيل البيبلوغرافية
العنوان: Association between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients.
المؤلفون: Anne-Lise Bienvenu, Pierre Pradat, Alexandra Plesa, Vincent Leclerc, Vincent Piriou, Jean-Luc Fellahi, Laurent Argaud, Thomas Rimmelé, Jean Menotti, Frédéric Aubrun, Jean-Christophe Richard, Marie-Claude Gagnieu, François Parant, Christian Chidiac, Gilles Leboucher, Michel Tod, Sylvain Goutelle
المصدر: PLoS ONE, Vol 16, Iss 11, p e0260656 (2021)
بيانات النشر: Public Library of Science (PLoS), 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for whom voriconazole demonstrated a large variability. The study aimed at describing factors associated with trough voriconazole concentrations in critically ill patients and evaluating the impact of voriconazole concentrations on adverse effects. A 2-year retrospective multicenter cohort study (NCT04502771) was conducted in six intensive care units. Adult patients who had at least one voriconazole TDM were included. Univariable and multivariable linear regression analyses were performed to identify predictors of voriconazole concentrations, and univariable logistic regression analysis, to study the relationship between voriconazole concentrations and adverse effects. During the 2-year study period, 70 patients were included. Optimal trough voriconazole concentrations were reported in 37 patients (52.8%), subtherapeutic in 20 (28.6%), and supratherapeutic in 13 (18.6%). Adverse effects were reported in six (8.6%) patients. SOFA score was identified as a factor associated with an increase in voriconazole concentration (p = 0.025), mainly in the group of patients who had SOFA score ≥ 10. Moreover, an increase in voriconazole concentration was shown to be a risk factor for occurrence of adverse effects (p = 0.011). In that respect, critically ill patients who received voriconazole treatment must benefit from a TDM, particularly if they have a SOFA score ≥ 10. Indeed, identifying patients who are overdosed will help to prevent voriconazole related adverse effects. This result is of utmost importance given the recognized COVID-19-associated pulmonary aspergillosis in ICU patients for whom voriconazole is among the recommended first-line treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0260656
URL الوصول: https://doaj.org/article/cd0d8eced2204a44936cdb5b3a8cd8c5
رقم الأكسشن: edsdoj.0d8eced2204a44936cdb5b3a8cd8c5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0260656