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In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT

التفاصيل البيبلوغرافية
العنوان: In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT
المؤلفون: Shaozhuang Yang, Liwei Liu, Yixin Chang, Ningning Zhang, Kun Liu, Liang Hong, Bingling Chen, Yue Zhao, Rui Hu, Junle Qu
المصدر: Journal of Innovative Optical Health Sciences, Vol 12, Iss 1, Pp 1950001-1-1950001-10 (2019)
بيانات النشر: World Scientific Publishing, 2019.
سنة النشر: 2019
المجموعة: LCC:Technology
LCC:Optics. Light
مصطلحات موضوعية: Optical coherence tomography, brain microcirculation, cerebral blood vessels, gold nanorods, Technology, Optics. Light, QC350-467
الوصف: In this paper, we proposed a contrast-enhanced homemade spectral domain optical coherence tomography (SD-OCT) method for monitoring of brain microcirculation. We used the polyethylene glycol (PEG)-ylated gold nanorods (GNRs) as a contrast-enhanced agent, obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood vessels. Owing to high scattering of the PEG-GNRs, more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20min, the enhancement then declined gradually for 60min. Our results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo, especially for studies of the brain microcirculation, which could be serviced for disease mechanism research and therapeutic drug monitoring.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1793-5458
1793-7205
17935458
Relation: https://doaj.org/toc/1793-5458; https://doaj.org/toc/1793-7205
DOI: 10.1142/S1793545819500019
URL الوصول: https://doaj.org/article/0e3dae3340284815adea9b32f214a548
رقم الأكسشن: edsdoj.0e3dae3340284815adea9b32f214a548
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17935458
17937205
DOI:10.1142/S1793545819500019