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Modulation of Rab GDP-Dissociation Inhibitor Trafficking and Expression by the Transmembrane Protein 59 (TMEM59)

التفاصيل البيبلوغرافية
العنوان: Modulation of Rab GDP-Dissociation Inhibitor Trafficking and Expression by the Transmembrane Protein 59 (TMEM59)
المؤلفون: Haifeng Wang, Tieqiao Wen
المصدر: Separations, Vol 9, Iss 11, p 341 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Physics
LCC:Chemistry
مصطلحات موضوعية: TMEM59, localization, protein, GDI1, GDI2, Physics, QC1-999, Chemistry, QD1-999
الوصف: Transmembrane protein 59 (TMEM59) is a type I transmembrane protein. However, the characterization and functions of TMEM59 in cells are not clear. Our results showed that TMEM59 localizes to vesicular structures. Further co-localization studies illustrated that TMEM59 is mainly distributed in the lysosome and acidic vesicular. TMEM59 movement between the nucleus and cell membrane was observed in living cells expressing TMEM59–EGFP fusion proteins. In addition, cell surface transport of amyloid precursor protein (APP) was significantly inhibited by TMEM59 and increased APP levels in HEK296T cells. TMEM59 also significantly inhibits transport of Rab GDP dissociation inhibitor alpha (GDI1) and Rab GDP dissociation inhibitor beta (GDI2), and further increases expression of GDI1 and GDI2 proteins in the cytoplasm. However, TMEM59 does not affect protein expression and localization of BACE2. These results suggest that TMEM59 may be involved in the packaging of acidic vesicles, modulated transport, and processing of APP, GDI1, and GDI2.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2297-8739
Relation: https://www.mdpi.com/2297-8739/9/11/341; https://doaj.org/toc/2297-8739
DOI: 10.3390/separations9110341
URL الوصول: https://doaj.org/article/0e4053f00be04261affbf6196080ed82
رقم الأكسشن: edsdoj.0e4053f00be04261affbf6196080ed82
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22978739
DOI:10.3390/separations9110341