دورية أكاديمية
Structural Insights into the Penicillin-Binding Protein 4 (DacB) from Mycobacterium tuberculosis
| العنوان: | Structural Insights into the Penicillin-Binding Protein 4 (DacB) from Mycobacterium tuberculosis |
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| المؤلفون: | Sung-Min Kang, Do-Hee Kim |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 2, p 983 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | Mycobacterium tuberculosis, antibiotics, penicillin-binding protein, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Mycobacterium tuberculosis, a major cause of mortality from a single infectious agent, possesses a remarkable mycobacterial cell envelope. Penicillin-Binding Proteins (PBPs) are a family of bacterial enzymes involved in the biosynthesis of peptidoglycan. PBP4 (DacB) from M. tuberculosis (MtbPBP4) has been known to function as a carboxypeptidase, and the role and significance of carboxypeptidases as targets for anti-tuberculosis drugs or antibiotics have been extensively investigated over the past decade. However, their precise involvement remains incompletely understood. In this study, we employed predictive modeling and analyzed the three-dimensional structure of MtbPBP4. Interestingly, MtbPBP4 displayed a distinct domain structure compared to its homologs. Docking studies with meropenem verified the presence of active site residues conserved in PBPs. These findings establish a structural foundation for comprehending the molecular function of MtbPBP4 and offer a platform for the exploration of novel antibiotics. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/2/983; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25020983 |
| URL الوصول: | https://doaj.org/article/0e5f39d36bc94bd7b4aea645775de01d |
| رقم الأكسشن: | edsdoj.0e5f39d36bc94bd7b4aea645775de01d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25020983 |