دورية أكاديمية
Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease
| العنوان: | Utility of Doppler-Ultrasound and Liver Elastography in the Evaluation of Patients with Suspected Pregnancy-Related Liver Disease |
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| المؤلفون: | Carla Serra, Elton Dajti, Chiara De Molo, Elisa Montaguti, Alberto Porro, Anna Seidenari, Emiliana Angilletta, Vito Bernardi, Ginevra Salsi, Sofia Maria Bakken, Marco Montagnani, Giuseppe Mazzella, Francesco Azzaroli |
| المصدر: | Journal of Clinical Medicine, Vol 12, Iss 4, p 1653 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | liver stiffness, elastography, Doppler-ultrasound, pre-eclampsia, liver disease, pregnancy, Medicine |
| الوصف: | Grayscale abdomen ultrasound (US) is routinely performed in pregnant women with suspected pregnancy-related liver dysfunction, but its diagnostic yield is very low. We aimed to investigate the association between Doppler-US findings, liver stiffness measurement (LSM) and different causes of pregnancy-related liver dysfunction. This is a prospective cohort study of pregnant women referred to our tertiary center for any suspected gastrointestinal disease between 2017 and 2019 and undergoing Doppler-US and liver elastography. Patients with previous liver disease were excluded from the analysis. For group comparisons of categorical and continuous variables, the chi-square test or Mann–Whitney test, and the McNemar test were used, as appropriate. A total of 112 patients were included in the final analysis, of whom 41 (36.6%) presented with suspected liver disease: 23 intrahepatic cholestasis of pregnancy (ICP), six with gestational hypertensive disorders and 12 cases with undetermined causes of elevated liver enzymes. Values of LSM were higher and significantly associated with a diagnosis of gestational hypertensive disorder (AUROC = 0.815). No significant differences at Doppler-US or LSM were found between ICP patients and controls. Patients with undetermined causes of hypertransaminasemia showed higher hepatic and splenic resistive indexes than controls, suggesting splanchnic congestion. The evaluation of Doppler-US and liver elastography is clinically useful in patients with suspected liver dysfunction during pregnancy. Liver stiffness represents a promising non-invasive tool for the assessment of patients with gestational hypertensive disorders. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12041653 2077-0383 |
| Relation: | https://www.mdpi.com/2077-0383/12/4/1653; https://doaj.org/toc/2077-0383 |
| DOI: | 10.3390/jcm12041653 |
| URL الوصول: | https://doaj.org/article/e0ea15d131494b579f496be42b76853f |
| رقم الأكسشن: | edsdoj.0ea15d131494b579f496be42b76853f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12041653 20770383 |
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| DOI: | 10.3390/jcm12041653 |