دورية أكاديمية
Antagonistic interaction between central glucagon-like Peptide-1 and oxytocin on diet-induced obesity mice
| العنوان: | Antagonistic interaction between central glucagon-like Peptide-1 and oxytocin on diet-induced obesity mice |
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| المؤلفون: | Jeonghoon Lee, Haneul Moon, Hyunji Lee, Yunkyeong Oh, Changyeon Kim, Young Hee Lee, Min Sun Kim, Cherl NamKoong, Hee Won Lee, Jung Hee Kim, Hyung Jin Choi |
| المصدر: | Heliyon, Vol 6, Iss 10, Pp e05190- (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Nervous system, Molecular neuroscience, Peptides, Diet, Metabolism, Glucagon-like peptide-1 (GLP-1), Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Glucagon-like peptide-1 (GLP-1), whose agonists are widely prescribed, is a peptide proven effective in reducing obesity. Similarly, oxytocin (OXT) is a peptide known to increase satiety and help reduce body weight. In the present study, we aimed to examine the metabolic effects of co-administration of GLP-1 and OXT in diet-induced obesity (DIO) mice to elucidate their functions and interactions in the central nervous system. To this end, 40 DIO mice were subjected to stereotaxic surgery for the installation of an osmotic minipump and intracerebroventricular administration of GLP-1, OXT, or both. Initially, it was anticipated that co-administration of these anorexigenic peptides would be as effective as, if not more than, either GLP-1 or OXT alone in providing metabolic benefits to the obese mice. Interestingly, co-administration of OXT and GLP-1 offset the reductions in body weight and food intake promoted by either peptide alone. Co-administration also negated the decrease in fat and increase in lean mass produced by either peptide alone. Moreover, co-administration showed an equivalent calorimetric benefit as either peptide alone. Therefore, these results suggest antagonistic, rather than synergistic or additive, effects of centrally administered GLP-1 and OXT that attenuate the metabolic benefits of either peptide. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844020320338; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2020.e05190 |
| URL الوصول: | https://doaj.org/article/a0ea4eebb55b493f8de873d77a25c341 |
| رقم الأكسشن: | edsdoj.0ea4eebb55b493f8de873d77a25c341 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2020.e05190 |