Functional Roles of DYRK2 as a Tumor Regulator

التفاصيل البيبلوغرافية
العنوان:	Functional Roles of DYRK2 as a Tumor Regulator
المؤلفون:	Yuta Mochimaru, Kiyotsugu Yoshida
المصدر:	Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 8539-8551 (2023)
بيانات النشر:	MDPI AG, 2023.
سنة النشر:	2023
المجموعة:	LCC:Biology (General)
مصطلحات موضوعية:	DYRK2, solid tumor, non-solid tumor, Biology (General), QH301-705.5
الوصف:	The dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) regulates the induction of apoptosis and DNA repair, metastasis inhibition, cell cycle G1/S transition, protein scaffold stability for E3 ligase complexes, and embryogenesis. Owing to these functions, DYRK2 is thought to regulate tumorigenesis, and its function in cancer has been investigated. Notably, DYRK2 has been reported to function as a tumor suppressor; however, it has also been reported to act as an oncogene in some cancers. This discrepancy makes it difficult to elucidate the conserved functions of DYRK2 in cancer. Here, we reviewed the functions of DYRK2 in various cancers. Patient tissue samples were evaluated for each cancer type. Although some studies have used cell lines and/or xenografts to elucidate the mechanism of DYRK2 function, these studies are not sufficient to understand the role of DYRK2 in cancers. In particular, studies using genetically modified mice would help us to understand the reported functional duality of DYRK2 in cancer.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	1467-3045 1467-3037
Relation:	https://www.mdpi.com/1467-3045/45/10/538; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045
DOI:	10.3390/cimb45100538
URL الوصول:	https://doaj.org/article/0eb3f7d9034a4694b3cd47a7452738e4
رقم الأكسشن:	edsdoj.0eb3f7d9034a4694b3cd47a7452738e4
قاعدة البيانات:	Directory of Open Access Journals

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الوصف
تدمد:	14673045 14673037
DOI:	10.3390/cimb45100538