دورية أكاديمية
Terpenoid Glucosides from Gentiana macrophylla That Attenuate TNF-α Induced Pulmonary Inflammation in A549 Cells
| العنوان: | Terpenoid Glucosides from Gentiana macrophylla That Attenuate TNF-α Induced Pulmonary Inflammation in A549 Cells |
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| المؤلفون: | Pei-Qi Huang, Yong-Xin Luo, Yu-Jia Zhang, Zhi-Xuan Li, Yan Wen, Kun Zhang, Dong-Li Li, Jing-Wei Jin, Ri-Hui Wu, Li-She Gan |
| المصدر: | Molecules, Vol 28, Iss 18, p 6613 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Organic chemistry |
| مصطلحات موضوعية: | Gentiana macrophylla (Gentianaceae), terpenoid glucosides, pulmonary inflammation, ELISA, Organic chemistry, QD241-441 |
| الوصف: | Four previously undescribed terpenoid glucosides, including one sesquiterpenoid di-glucoside (1), two new iridoid glucosides (2, 3), and a new triterpenoid tri-glucoside (4), were isolated from a 70% ethanol extract of the root of Gentiana macrophylla (Gentianaceae), along with eight known terpenoids. Their structures were determined by spectroscopic techniques, including 1D, 2D NMR, and HRMS (ESI), as well as chemical methods. The absolute configuration of compound 1 was determined by quantum chemical calculation of its theoretical electronic circular dichroism (ECD) spectrum. The sugar moieties of all the new compounds were confirmed to be D-glucose by GC analysis after acid hydrolysis and acetylation. Anti-pulmonary inflammation activity of the iridoids were evaluated on a TNF-α induced inflammation model in A549 cells. Compound 2 could significantly alleviate the release of proinflammatory cytokines IL-1β and IL-8 and increase the expression of anti-inflammatory cytokine IL-10. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 28186613 1420-3049 |
| Relation: | https://www.mdpi.com/1420-3049/28/18/6613; https://doaj.org/toc/1420-3049 |
| DOI: | 10.3390/molecules28186613 |
| URL الوصول: | https://doaj.org/article/a0ec2db93daa4d7c9cfd5a9c36f51897 |
| رقم الأكسشن: | edsdoj.0ec2db93daa4d7c9cfd5a9c36f51897 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 28186613 14203049 |
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| DOI: | 10.3390/molecules28186613 |