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Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG

التفاصيل البيبلوغرافية
العنوان: Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG
المؤلفون: Kasey Schalich, Seesandra Rajagopala, Suman Das, Ryan O’Connell, Fang Yan
المصدر: Frontiers in Microbiology, Vol 13 (2023)
بيانات النشر: Frontiers Media S.A., 2023.
سنة النشر: 2023
المجموعة: LCC:Microbiology
مصطلحات موضوعية: bacterial transporter, bacterial metabolism, commensal bacterium, intestinal epithelial cell, RNA sequencing, the microbial-host interaction, Microbiology, QR1-502
الوصف: IntroductionIntestinal epithelial cells (IECs) provide the frontline responses to the gut microbiota for maintaining intestinal homeostasis. Our previous work revealed that IEC-derived components promote the beneficial effects of a commensal and probiotic bacterium, Lactobacillus rhamnosus GG (LGG). This study aimed to elucidate the regulatory effects of IEC-derived components on LGG at the molecular level.MethodsDifferential gene expression in LGG cultured with IEC-derived components at the timepoint between the exponential and stationary phase was studied by RNA sequencing and functional analysis.ResultsThe transcriptomic profile of LGG cultured with IEC-derived components was significantly different from that of control LGG, with 231 genes were significantly upregulated and 235 genes significantly down regulated (FDR
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1664-302X
Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2022.1051310/full; https://doaj.org/toc/1664-302X
DOI: 10.3389/fmicb.2022.1051310
URL الوصول: https://doaj.org/article/0ecdead976da4247bafc8aeef2318c34
رقم الأكسشن: edsdoj.0ecdead976da4247bafc8aeef2318c34
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1664302X
DOI:10.3389/fmicb.2022.1051310