دورية أكاديمية

Randomised trial of the clinical and cost effectiveness of a supraglottic airway device compared with tracheal intubation for in-hospital cardiac arrest (AIRWAYS-3): Protocol, design and implementation

التفاصيل البيبلوغرافية
العنوان: Randomised trial of the clinical and cost effectiveness of a supraglottic airway device compared with tracheal intubation for in-hospital cardiac arrest (AIRWAYS-3): Protocol, design and implementation
المؤلفون: Scott Watkins, Fatimah J. Chowdhury, Chloe Norman, Stephen J. Brett, Keith Couper, Laura Goodwin, Doug W. Gould, David AE. Harrison, Anower Hossain, Ranjit Lall, James Mason, Jerry P. Nolan, Henry Nwankwo, Gavin D. Perkins, Katie Samuel, Behnaz Schofield, Jasmeet Soar, Kath Starr, Matthew Thomas, Sarah Voss, Jonathan R. Benger
المصدر: Resuscitation Plus, Vol 15, Iss , Pp 100430- (2023)
بيانات النشر: Elsevier, 2023.
سنة النشر: 2023
المجموعة: LCC:Specialties of internal medicine
مصطلحات موضوعية: In-hospital cardiac arrest, Cardiopulmonary resuscitation, Airway management, Endotracheal intubation, Laryngeal mask airway, Randomized clinical trial, Specialties of internal medicine, RC581-951
الوصف: Survival from in-hospital cardiac arrest is approximately 18%, but for patients who require advanced airway management survival is lower. Those who do survive are often left with significant disability. Traditionally, resuscitation of cardiac arrest patients has included tracheal intubation, however insertion of a supraglottic airway has gained popularity as an alternative approach to advanced airway management. Evidence from out-of-hospital cardiac arrest suggests no significant differences in mortality or morbidity between these two approaches, but there is no randomised evidence for airway management during in-hospital cardiac arrest.The aim of the AIRWAYS-3 randomised trial, described in this protocol paper, is to determine the clinical and cost effectiveness of a supraglottic airway versus tracheal intubation during in-hospital cardiac arrest. Patients will be allocated randomly to receive either a supraglottic airway or tracheal intubation as the initial advanced airway management. We will also estimate the relative cost-effectiveness of these two approaches. The primary outcome is functional status, measured using the modified Rankin Scale at hospital discharge or 30 days post-randomisation, whichever occurs first.AIRWAYS-3 presents ethical challenges regarding patient consent and data collection. These include the enrolment of unconscious patients without prior consent in a way that avoids methodological bias. Other complexities include the requirement to randomise patients efficiently during a time-critical cardiac arrest. Many of these challenges are encountered in other emergency care research; we discuss our approaches to addressing them.Trial registration: ISRCTN17720457. Prospectively registered on 29/07/2022.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2666-5204
Relation: http://www.sciencedirect.com/science/article/pii/S2666520423000735; https://doaj.org/toc/2666-5204
DOI: 10.1016/j.resplu.2023.100430
URL الوصول: https://doaj.org/article/0fb0c1e5c70b4edf9e7c17ff68cd5b72
رقم الأكسشن: edsdoj.0fb0c1e5c70b4edf9e7c17ff68cd5b72
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:26665204
DOI:10.1016/j.resplu.2023.100430