التفاصيل البيبلوغرافية
العنوان:
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
المؤلفون:
Josepmaria Argemi , Maria U. Latasa , Stephen R. Atkinson , Ilya O. Blokhin , Veronica Massey , Joel P. Gue , Joaquin Cabezas , Juan J. Lozano , Derek Van Booven , Aaron Bell , Sheng Cao , Lawrence A. Vernetti , Juan P. Arab , Meritxell Ventura-Cots , Lia R. Edmunds , Constantino Fondevila , Peter Stärkel , Laurent Dubuquoy , Alexandre Louvet , Gemma Odena , Juan L. Gomez , Tomas Aragon , Jose Altamirano , Juan Caballeria , Michael J. Jurczak , D. Lansing Taylor , Carmen Berasain , Claes Wahlestedt , Satdarshan P. Monga , Marsha Y. Morgan , Pau Sancho-Bru , Philippe Mathurin , Shinji Furuya , Carolin Lackner , Ivan Rusyn , Vijay H. Shah , Mark R. Thursz , Jelena Mann , Matias A. Avila , Ramon Bataller
المصدر:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
بيانات النشر:
Nature Portfolio, 2019.
سنة النشر:
2019
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Alcoholic hepatitis, a common cause of liver failure, lacks effective treatment. Here, the authors show altered hepatic HNF4a isoform expression and hypermethylation of its target genes in patients. HNF4a dysregulation is improved in vitro by TGFb or PPARg modulation suggesting potential therapeutic avenues.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-019-11004-3
URL الوصول:
https://doaj.org/article/0fb71062dc154a909e1831b9bf41223d
رقم الأكسشن:
edsdoj.0fb71062dc154a909e1831b9bf41223d
قاعدة البيانات:
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