دورية أكاديمية
Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson’s disease model by AMPK-mediated autophagy
| العنوان: | Mitochonic acid 5 ameliorates the motor deficits in the MPTP-induced mouse Parkinson’s disease model by AMPK-mediated autophagy |
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| المؤلفون: | Juan Wan, Yijiang Gao, Jian Tan, Shanqing Yi, Kailiang Huang, Yao Liu, Dong Chang, Jiali Xie, Shuangxi Chen, Heng Wu |
| المصدر: | Folia Neuropathologica, Vol 60, Iss 3, Pp 329-337 (2022) |
| بيانات النشر: | Termedia Publishing House, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | parkinson’s disease (pd), mitochonic acid 5 (ma-5), ampk, autophagy., Medicine |
| الوصف: | Parkinson’s disease (PD) is a well-known neurodegenerative disorder characterized by the degeneration of dopaminergic neurons, and oxidative stress and neuroinflammation are also associated with the pathogenesis of PD. Mitochonic acid 5 (MA-5), an analogue of indole-3-acetic acid, exerts key protective roles in inhibiting apoptosis, oxidative stress and neuroinflammation in multiple diseases. However, whether MA-5 can be beneficial for PD remains unclear. Hence, the aim of this study was to investigate the neuroprotective role of MA-5 in PD. In the current study, MPTP-challenged mice were treated as the in vivo model, and the effect of MA-5 on the motor function, neuronal survival, oxidative stress, neuroinflammation and the underlying mechanisms involved with AMPK and autophagy were determined. We revealed that MA-5 obviously up-regulated the phosphorylation of AMPK and promoted the autophagy (indicated by the increased LC3II/LC3I, parkin, pink and decreased p62) in substantia nigra (SN), ameliorated the motor deficits, up-regulated the expression of TH, suppressed the inflammation (indicated by the decreased protein levels of interleukin (IL)-1b, IL-6, tumour necrosis factor a) in SN in MPTP-induced mice. However, these patterns were reversed after the treatment of Compound C, an inhibitor of AMPK; also, after the application of CSA, an inhibitor of autophagy, MA-5 cannot play against the neurotoxicity of MPTP in mice. These combined results suggest that MA-5 can protect against MPTP-induced neurotoxicity to ameliorate the impaired motor function, which may be modulated via activation of AMPK-induced autophagy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1641-4640 1509-572X |
| Relation: | https://www.termedia.pl/Mitochonic-acid-5-ameliorates-the-motor-deficits-in-the-MPTP-induced-mouse-Parkinson-s-disease-model-by-AMPK-mediated-autophagy,20,47655,1,1.html; https://doaj.org/toc/1641-4640; https://doaj.org/toc/1509-572X |
| DOI: | 10.5114/fn.2022.118796 |
| URL الوصول: | https://doaj.org/article/100057c4521145b48b001b246336bbdb |
| رقم الأكسشن: | edsdoj.100057c4521145b48b001b246336bbdb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16414640 1509572X |
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| DOI: | 10.5114/fn.2022.118796 |