دورية أكاديمية
Pazopanib for renal cell carcinoma leads to elevated mean arterial pressures in a murine model
العنوان: | Pazopanib for renal cell carcinoma leads to elevated mean arterial pressures in a murine model |
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المؤلفون: | Amber Kempton, Cody Justice, Aaron Guo, Matthew Cefalu, Michael Makara, Paul Janssen, Thai H Ho, Sakima A Smith |
المصدر: | Clinical and Experimental Hypertension, Vol 40, Iss 6, Pp 524-533 (2018) |
بيانات النشر: | Taylor & Francis Group, 2018. |
سنة النشر: | 2018 |
المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
مصطلحات موضوعية: | renal cell carcinoma, hypertension, pazopanib, tyrosine kinase inhibitors, cardio-oncology, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
الوصف: | Background: In the setting of metastatic RCC (mRCC), pazopanib is approved as first line therapy. Unfortunately treatment may lead to cardiotoxicity such as hypertension, heart failure, and myocardial ischemia. Objective: Define the in vivo role of pazopanib in the development of cardiotoxicity. Methods: Wild type mice were dosed for 42 days via oral gavage, and separated into control and treatment (pazopanib) groups. Baseline ECG’s, echocardiograms, and blood pressures were recorded. At the conclusion of the study functional parameters were again recorded, and animals were used for pathological, histological, and protein analysis. Results: After 2 weeks of dosing with pazopanib, the treatment group exhibited a statistically significant increase in mean arterial pressure compared to control mice (119 ± 11.7 mmHg versus 108 ± 8.2 mmHg, p = 0.049). Treatment with pazopanib led to a significant reduction in the cardiac output of mice. Conclusion: Our findings in mice clearly demonstrate that treatment with pazopanib leads to a significant elevation in blood pressure after 2 weeks of dosing and this persists for the duration of dosing. The continued development of the cardio-oncology field will be paramount in providing optimal oncologic care while simultaneously improving cardiac outcomes through further investigation into the mechanisms of CV toxicity. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1064-1963 1525-6006 10641963 |
Relation: | https://doaj.org/toc/1064-1963; https://doaj.org/toc/1525-6006 |
DOI: | 10.1080/10641963.2017.1403623 |
URL الوصول: | https://doaj.org/article/ee101e36ea8b41729efeb386edef388f |
رقم الأكسشن: | edsdoj.101e36ea8b41729efeb386edef388f |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 10641963 15256006 |
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DOI: | 10.1080/10641963.2017.1403623 |