دورية أكاديمية
أعرض في EDS

AM-18002, a derivative of natural anmindenol A, enhances radiosensitivity in mouse breast cancer cells.

التفاصيل البيبلوغرافية
العنوان: AM-18002, a derivative of natural anmindenol A, enhances radiosensitivity in mouse breast cancer cells.
المؤلفون: Da-Young Eum, Myeonggyo Jeong, Soon-Yong Park, Jisu Kim, Yunho Jin, Jeyun Jo, Jae-Woong Shim, Seoung Rak Lee, Seong-Joon Park, Kyu Heo, Hwayoung Yun, Yoo-Jin Choi
المصدر: PLoS ONE, Vol 19, Iss 4, p e0296989 (2024)
بيانات النشر: Public Library of Science (PLoS), 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Natural anmindenol A isolated from the marine-derived bacteria Streptomyces sp. caused potent inhibition of inducible nitric oxide synthase without any significant cytotoxicity. This compound consists of a structurally unique 3,10-dialkylbenzofulvene skeleton. We previously synthesized and screened the novel derivatives of anmindenol A and identified AM-18002, an anmindenol A derivative, as a promising anticancer agent. The combination of AM-18002 and ionizing radiation (IR) improved anticancer effects, which were exerted by promoting apoptosis and inhibiting the proliferation of FM3A mouse breast cancer cells. AM-18002 increased the production of reactive oxygen species (ROS) and was more effective in inducing DNA damage. AM-18002 treatment was found to inhibit the expansion of myeloid-derived suppressor cells (MDSC), cancer cell migration and invasion, and STAT3 phosphorylation. The AM-18002 and IR combination synergistically induced cancer cell death, and AM-18002 acted as a potent anticancer agent by increasing ROS generation and blocking MDSC-mediated STAT3 activation in breast cancer cells.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0296989&type=printable; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0296989&type=printable
DOI: 10.1371/journal.pone.0296989
URL الوصول: https://doaj.org/article/ddcaa1048c7d44278990fcf0760bf3d7
رقم الأكسشن: edsdoj.1048c7d44278990fcf0760bf3d7
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0296989&type=printable