دورية أكاديمية
Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer
| العنوان: | Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer |
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| المؤلفون: | Ana Jotic Ph.D., M.D., Jovica Milovanovic Ph.D., M.D., Katarina Savic-Vujovic Ph.D., M.D., Zorana Radin M.D., Branislava Medic Ph.D., M.D., Miljan Folic Ph.D., M.D., Bojan Pavlovic Ph.D., M.D., Aleksandar Vujovic M.D., Dusko Dundjerovic Ph.D., M.D. |
| المصدر: | Dose-Response, Vol 20 (2022) |
| بيانات النشر: | SAGE Publishing, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Objective The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. Material and Methods A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referral center. Tumor tissue was immunohistochemically stained for T-cell markers (CD4 and CD8), and levels of cytokines (IL-6 and IL-8) and C-reactive protein were analyzed from blood samples. Results Overall 3-year survival (OS) of patients included in the study was 69.2% and the disease specific survival (DSS) 72.5%. Higher expression of CD4 + and CD8 + were significant prognostic factors with positive impact on both OS and DSS in univariate analysis, but not in multivariate analysis. Levels of IL-8 were a significant predictor of 3-year OS and DSS survival in patients with advanced laryngeal cancer but not levels of IL-6 and CRP values. Conclusion Though high expression of CD4 and CD8 were demonstrated in the tumor tissue, but their prognostic role was not established. Higher values of IL-8 proved to be significant negative predictor of DSS. This could further collaborate the inclusion of combination of biomarkers in assessment of favorable treatment choice in patients with advanced laryngeal carcinoma. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1559-3258 15593258 |
| Relation: | https://doaj.org/toc/1559-3258 |
| DOI: | 10.1177/15593258221115537 |
| URL الوصول: | https://doaj.org/article/c1070fc24c7241e5bdb0dc519186d9b2 |
| رقم الأكسشن: | edsdoj.1070fc24c7241e5bdb0dc519186d9b2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15593258 |
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| DOI: | 10.1177/15593258221115537 |