دورية أكاديمية
Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice
| العنوان: | Postweaning Grouping as a Strategy to Reduce Singly Housed Male Mice |
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| المؤلفون: | Roger Grífols, Carolina Zamora, Iván Ortega-Saez, Garikoitz Azkona |
| المصدر: | Animals, Vol 10, Iss 11, p 2135 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Veterinary medicine LCC:Zoology |
| مصطلحات موضوعية: | juvenile, pubescent, aggressiveness, testosterone, mouse, Veterinary medicine, SF600-1100, Zoology, QL1-991 |
| الوصف: | Rearing laboratory mice in groups is important since social isolation after weaning induces brain alterations, which entails behavioral abnormalities in adulthood. Age is an important factor when grouping males of different litters due to inter-male aggressiveness. The aim of this study was to determine whether newly weaned mice could safely be grouped with late juvenile or early and late pubescent mice, and whether cage cleaning, the number of the hosting group members and testosterone plasma levels have any influence. Newly weaned C57BL/6J, CD1, and SCID Beige male mice were systematically grouped with same strain late juvenile, early or late pubescent male mice in clean or dirty cages of 1, 2 or 3 hosting members. We also analyzed plasma testosterone levels at different postnatal days. Our result showed that only strain and hosting male’s age influence agonistic behavior toward newly weaned mice. Thus, in order not to house a recently weaned male alone, we would recommend grouping it with late juvenile same strain mice in all studied strains. In the same way, CD1 and SCID Beige pubescent mice will admit a newly weaned mouse in their group. However, we would not recommend grouping newly weaned and pubescent C57BL/6J males. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-2615 |
| Relation: | https://www.mdpi.com/2076-2615/10/11/2135; https://doaj.org/toc/2076-2615 |
| DOI: | 10.3390/ani10112135 |
| URL الوصول: | https://doaj.org/article/eeee109db2134075b97bc5fb577a559e |
| رقم الأكسشن: | edsdoj.109db2134075b97bc5fb577a559e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20762615 |
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| DOI: | 10.3390/ani10112135 |